Altered γ-catenin expression correlates with poor survival in patients with bladder cancer

K. N. Syrigos, K. Harrington, J. Waxman, T. Krausz, M. Pignatelli

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63 Citations (Scopus)

Abstract

Purpose: We studied the expression of α-, β-, γ- catenin and E- cadherin in transitional cell carcinoma (TCC) and normal bladder epithelium and correlated these results with pathological and clinical parameters. Materials and Methods: We used an avidin-biotin immunoperoxidase technique to examine the cellular localization of α-catenin, β-catenin, γ-catenin and E-cadherin in 68 TCC and 14 normal bladder biopsies. Results: E-cadherin, α- catenin, β-catenin and γ-catenin were expressed in a normal membranous pattern in all normal bladder epithelium specimens. Loss of normal surface E- cadherin, α-catenin, β-catenin and γ-catenin expression was found in 52/68 (76.4%) tumors, 57/68 (83.8%) tumors, 54/68 (79.4%) tumors and 54/68 (79.4%) tumors (p <0.001). There was a significant correlation between the loss of normal membranous expression of catenins and E-cadherin and increased grade (p <0.05). A highly significant correlation was observed between the loss of expression of E-cadherin, α- catenin and γ-catenin, but not β-catenin, with increased TNM stage (p <0.05). The abnormal expression of γ-catenin as well as E-cadherin was correlated with poor survival (p <0.05). Conclusions: E-cadherin-γ-catenin complex may be a useful prognostic marker in bladder cancer. Work is in progress to establish whether normal membranous catenin expression can be enhanced by gene transfer or biological therapy to induce a less invasive and metastatic phenotype.

Original languageEnglish
Pages (from-to)1889-1893
Number of pages5
JournalJournal of Urology
Volume160
Issue number5
DOIs
Publication statusPublished - Nov 1998

Keywords

  • Adhesion
  • E-cadherin-catenins complex
  • Prognostic markers

ASJC Scopus subject areas

  • Urology

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