An action spectrum for the production of cis-urocanic acid in human skin in vivo

Pauline McLoone, Eniko Simics, Alan Barton, Mary Norval, Neil K. Gibbs

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Urocanic acid (UCA) is present at millimolar concentrations in mammalian epidermis and undergoes photo-isomerization from the naturally occurring trans-isomer to the cis-isomer on exposure to ultraviolet radiation (UVR). Cis-UCA causes downregulation of various immune responses in mouse and human experimental models and has been proposed as both a chromophore and a mediator of UV-induced immune suppression. In this study, the wavelength dependence from 260-340 nm for trans to cis-UCA photoisomerization in human skin was analyzed in five healthy volunteers. The resulting action spectrum demonstrated maximal cis-UCA production in the UVB spectral region of 280-310 nm. This spectral peak is red-shifted to longer wavelengths compared with the erythemal action spectrum. The cis-UCA action spectrum can be used to predict the ability of sunscreens to protect against UVR-induced cis-UCA formation and may assist in explaining discrepancies between sunscreens' abilities to protect against erythema and photoimmunosuppression.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalJournal of Investigative Dermatology
Volume124
Issue number5
DOIs
Publication statusPublished - May 2005
Externally publishedYes

Fingerprint

NSC 153174
Urocanic Acid
Skin
Sun hoods
Photoisomerization
Sunscreening Agents
Ultraviolet radiation
Isomers
Radiation
Wavelength
Erythema
Chromophores
Epidermis
Action Spectrum
Healthy Volunteers
Theoretical Models
Down-Regulation

Keywords

  • Skin
  • Urocanic acid
  • UV radiation

ASJC Scopus subject areas

  • Dermatology

Cite this

An action spectrum for the production of cis-urocanic acid in human skin in vivo. / McLoone, Pauline; Simics, Eniko; Barton, Alan; Norval, Mary; Gibbs, Neil K.

In: Journal of Investigative Dermatology, Vol. 124, No. 5, 05.2005, p. 1071-1074.

Research output: Contribution to journalArticle

McLoone, Pauline ; Simics, Eniko ; Barton, Alan ; Norval, Mary ; Gibbs, Neil K. / An action spectrum for the production of cis-urocanic acid in human skin in vivo. In: Journal of Investigative Dermatology. 2005 ; Vol. 124, No. 5. pp. 1071-1074.
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