An electromagnetic steering system for magnetic nanoparticle drug delivery

Ton Duc Do, Yeongil Noh, Myeong Ok Kim, Jungwon Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Targeted delivery of pharmaceutical agents to the brain using magnetic nanoparticles (MNPs) is an efficient technique to transport molecules to disease locations. MNPs can cross the blood-brain barrier (BBB) and can be concentrated at a specific location in the brain using non-invasive electromagnetic forces. The proposed EMA consists of two coil-core system. The cores are added in the center of each coil to concentrate the flux in the region of interest. The EMA can enhance the gradient field 10 times compared to only coil system and generate the maximum magnetic field of 160 mT and 5.6 T/m. A 12-kW direct-current power supply was used to generate sufficient magnetic forces on the MNPs by regulating the input currents of the coils. Effective guidance of MNPs is demonstrated via simulations and experiments using 800-nm-diameter MNPs in a Y-shaped channel. The developed EMA system has high potentials to increase BBB crossing of MNPs for efficient drug targeting to brain regions.

Original languageEnglish
Title of host publication2015 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages528-531
Number of pages4
ISBN (Electronic)9781467379700
DOIs
Publication statusPublished - Dec 16 2015
Event12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015 - Goyang City, Korea, Republic of
Duration: Oct 28 2015Oct 30 2015

Publication series

Name2015 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015

Other

Other12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015
CountryKorea, Republic of
CityGoyang City
Period10/28/1510/30/15

Keywords

  • Drug delivery
  • electromagnetic actuator
  • magnetic drug targeting
  • magnetic nanoparticles (MNPs)

ASJC Scopus subject areas

  • Artificial Intelligence
  • Human-Computer Interaction

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  • Cite this

    Do, T. D., Noh, Y., Kim, M. O., & Yoon, J. (2015). An electromagnetic steering system for magnetic nanoparticle drug delivery. In 2015 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015 (pp. 528-531). [7358822] (2015 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/URAI.2015.7358822