@inproceedings{0b00e33c1c454110b2ec6ff6d28871d0,
title = "An electromagnetic steering system for magnetic nanoparticle drug delivery",
abstract = "Targeted delivery of pharmaceutical agents to the brain using magnetic nanoparticles (MNPs) is an efficient technique to transport molecules to disease locations. MNPs can cross the blood-brain barrier (BBB) and can be concentrated at a specific location in the brain using non-invasive electromagnetic forces. The proposed EMA consists of two coil-core system. The cores are added in the center of each coil to concentrate the flux in the region of interest. The EMA can enhance the gradient field 10 times compared to only coil system and generate the maximum magnetic field of 160 mT and 5.6 T/m. A 12-kW direct-current power supply was used to generate sufficient magnetic forces on the MNPs by regulating the input currents of the coils. Effective guidance of MNPs is demonstrated via simulations and experiments using 800-nm-diameter MNPs in a Y-shaped channel. The developed EMA system has high potentials to increase BBB crossing of MNPs for efficient drug targeting to brain regions.",
keywords = "Drug delivery, electromagnetic actuator, magnetic drug targeting, magnetic nanoparticles (MNPs)",
author = "Do, {Ton Duc} and Yeongil Noh and Kim, {Myeong Ok} and Jungwon Yoon",
note = "Funding Information: This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (2012-0009524) Publisher Copyright: {\textcopyright} 2015 IEEE.; 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015 ; Conference date: 28-10-2015 Through 30-10-2015",
year = "2015",
month = dec,
day = "16",
doi = "10.1109/URAI.2015.7358822",
language = "English",
series = "2015 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "528--531",
booktitle = "2015 12th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2015",
address = "United States",
}
