An extensive phenotypic characterization of the hTNFα transgenic mice

Michael D. Hayward, Beverly K. Jones, Arman Saparov, Heather S. Hain, Anne Cecile Trillat, Michelle M. Bunzel, Aaron Corona, Bifang Li-Wang, Bryan Strenkowski, Caroline Giordano, Hai Shen, Emily Arcamone, Jeffrey Weidlick, Maria Vilensky, Marina Tugusheva, Roland H. Felkner, William Campbell, Yu Rao, David S. Grass, Olesia Buiakova

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background. Tumor necrosis factor alpha (TNFα) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFα (hTNFα) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an hTNFα transgenic mouse line. Results. In addition to arthritis, these hTNFα transgenic mice demonstrated major alterations in body composition, metabolic rate, leptin levels, response to a high-fat diet, bone mineral density and content, impaired fertility and male sexual function. Many phenotypes displayed an earlier onset and a higher degree of severity in males, pointing towards a significant degree of sexual dimorphism in response to deregulated expression of TNFα. Conclusion. These results highlight the potential usefulness of this transgenic model as a resource for studying the progressive effects of constitutively expressed low levels of circulating TNFα, a condition mimicking that observed in a number of human pathological conditions.

Original languageEnglish
Article number13
JournalBMC Physiology
Volume7
DOIs
Publication statusPublished - 2007
Externally publishedYes

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Transgenic Mice
Tumor Necrosis Factor-alpha
Bone Density
Physiological Phenomena
Cachexia
High Fat Diet
Pathologic Processes
Leptin
Body Composition
Sex Characteristics
Arthritis
Fertility
Coronary Artery Disease
Rheumatoid Arthritis
Obesity
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hayward, M. D., Jones, B. K., Saparov, A., Hain, H. S., Trillat, A. C., Bunzel, M. M., ... Buiakova, O. (2007). An extensive phenotypic characterization of the hTNFα transgenic mice. BMC Physiology, 7, [13]. https://doi.org/10.1186/1472-6793-7-13

An extensive phenotypic characterization of the hTNFα transgenic mice. / Hayward, Michael D.; Jones, Beverly K.; Saparov, Arman; Hain, Heather S.; Trillat, Anne Cecile; Bunzel, Michelle M.; Corona, Aaron; Li-Wang, Bifang; Strenkowski, Bryan; Giordano, Caroline; Shen, Hai; Arcamone, Emily; Weidlick, Jeffrey; Vilensky, Maria; Tugusheva, Marina; Felkner, Roland H.; Campbell, William; Rao, Yu; Grass, David S.; Buiakova, Olesia.

In: BMC Physiology, Vol. 7, 13, 2007.

Research output: Contribution to journalArticle

Hayward, MD, Jones, BK, Saparov, A, Hain, HS, Trillat, AC, Bunzel, MM, Corona, A, Li-Wang, B, Strenkowski, B, Giordano, C, Shen, H, Arcamone, E, Weidlick, J, Vilensky, M, Tugusheva, M, Felkner, RH, Campbell, W, Rao, Y, Grass, DS & Buiakova, O 2007, 'An extensive phenotypic characterization of the hTNFα transgenic mice', BMC Physiology, vol. 7, 13. https://doi.org/10.1186/1472-6793-7-13
Hayward, Michael D. ; Jones, Beverly K. ; Saparov, Arman ; Hain, Heather S. ; Trillat, Anne Cecile ; Bunzel, Michelle M. ; Corona, Aaron ; Li-Wang, Bifang ; Strenkowski, Bryan ; Giordano, Caroline ; Shen, Hai ; Arcamone, Emily ; Weidlick, Jeffrey ; Vilensky, Maria ; Tugusheva, Marina ; Felkner, Roland H. ; Campbell, William ; Rao, Yu ; Grass, David S. ; Buiakova, Olesia. / An extensive phenotypic characterization of the hTNFα transgenic mice. In: BMC Physiology. 2007 ; Vol. 7.
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AU - Bunzel, Michelle M.

AU - Corona, Aaron

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AU - Strenkowski, Bryan

AU - Giordano, Caroline

AU - Shen, Hai

AU - Arcamone, Emily

AU - Weidlick, Jeffrey

AU - Vilensky, Maria

AU - Tugusheva, Marina

AU - Felkner, Roland H.

AU - Campbell, William

AU - Rao, Yu

AU - Grass, David S.

AU - Buiakova, Olesia

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