Povyshenie aktivnosti estestvennykh killerov u krys s nedostatochnost'yu vitamina A

Translated title of the contribution: An increase in activity of natural killer cells in rats with vitamin A deficiency

A S Saparov, I Ia Kon, A T Sharmanov

Research output: Contribution to journalArticle

Abstract

A study was made of the effect of different supply of rats with vitamin A on the membranotoxic activity of natural killers, which was assessed with the use of target cells K-562 labeled with 3H-uridine incubated jointly with splenocytes. The animals were kept on a semi-synthetic diet deprived of vitamin A. This led to a reduction of the body weight and retinol content in the liver. At the same time the membranotoxic activity of splenocytes rose 1.5-fold as compared with controls kept on a balanced diet. Administration of retinol palmitate to the animals with vitamin A deficiency suppressed the activity of natural killers, raising the retinol content in the liver. The intensity of the effects in question depended on the ratio of the effector cells and targets. The possible mechanisms of the potentiation of natural antitumor resistance in animals with vitamin A deficiency are under discussion.

Original languageRussian
Pages (from-to)30-2
Number of pages3
JournalVoprosy Pitaniia
Issue number2
Publication statusPublished - Mar 1 1989

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Vitamin A Deficiency
Vitamin A
Natural Killer Cells
Formulated Food
Uridine
Liver
Innate Immunity
Body Weight
Diet

Keywords

  • Animals
  • Body Weight
  • Cytotoxicity, Immunologic
  • Killer Cells, Natural
  • Liver
  • Rats
  • Rats, Inbred Strains
  • Vitamin A
  • Vitamin A Deficiency
  • English Abstract
  • Journal Article

Cite this

Povyshenie aktivnosti estestvennykh killerov u krys s nedostatochnost'yu vitamina A. / Saparov, A S; Kon, I Ia; Sharmanov, A T.

In: Voprosy Pitaniia, No. 2, 01.03.1989, p. 30-2.

Research output: Contribution to journalArticle

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AB - A study was made of the effect of different supply of rats with vitamin A on the membranotoxic activity of natural killers, which was assessed with the use of target cells K-562 labeled with 3H-uridine incubated jointly with splenocytes. The animals were kept on a semi-synthetic diet deprived of vitamin A. This led to a reduction of the body weight and retinol content in the liver. At the same time the membranotoxic activity of splenocytes rose 1.5-fold as compared with controls kept on a balanced diet. Administration of retinol palmitate to the animals with vitamin A deficiency suppressed the activity of natural killers, raising the retinol content in the liver. The intensity of the effects in question depended on the ratio of the effector cells and targets. The possible mechanisms of the potentiation of natural antitumor resistance in animals with vitamin A deficiency are under discussion.

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