Anaesthesia recommendations for patients suffering from Immune thrombocytopenia (ITP)

Şule Özbilgin, Tanu Mehta, James B. Bussel, DImitri Poddighe

Research output: Contribution to journalReview article

Abstract

Immune thrombocytopenia, previously known as idiopathic thrombocytopenic purpura (ITP), is an autoimmune disease that is related to anti-platelet immunoglobulin (IgG) production. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. The production of these autoantibodies by B cells depends on a number of cellular mechanisms that form a network of modulation, with T cells playing a pivotal role in pathophysiology. T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP [1-3]. Other causes are included genetic factors (immune genes- FcR, immune syndromes, platelet antigens) and susceptibility to initial event (infection, inflamination) [4]. Immune thrombocytopenia is characterised by increased mucocutaneous haemorrhage risk with low platelet counts [5].

Original languageEnglish
Pages (from-to)S458-S473
JournalAnasthesiologie und Intensivmedizin
Volume58
Issue number5
DOIs
Publication statusPublished - May 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

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