Abstract
Immune thrombocytopenia, previously known as idiopathic thrombocytopenic purpura (ITP), is an autoimmune disease that is related to anti-platelet immunoglobulin (IgG) production. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. The production of these autoantibodies by B cells depends on a number of cellular mechanisms that form a network of modulation, with T cells playing a pivotal role in pathophysiology. T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP [1-3]. Other causes are included genetic factors (immune genes- FcR, immune syndromes, platelet antigens) and susceptibility to initial event (infection, inflamination) [4]. Immune thrombocytopenia is characterised by increased mucocutaneous haemorrhage risk with low platelet counts [5].
Original language | English |
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Pages (from-to) | S458-S473 |
Journal | Anasthesiologie und Intensivmedizin |
Volume | 58 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 1 2017 |
Externally published | Yes |
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Anesthesiology and Pain Medicine