Angiotensin converting enzyme (ACE) polymorphism and its relation to progression liver cirrhosis caused by chronic hepatitis c in the Kazakh population

To study the inheritance value of the polymorphism of the gene angiotensin single nucleotide polymorphism located in (AT-6) promoter-6 region in the progression of cirrhosis as a result of viral hepatitis C. Material and methods: This prospective study was performed on 120 patients having chronic hepatitis C, 53 of them are women and 67 are men, and on healthy donors 70 people. Patients were divided into groups: 1 group - patients diagnosed with chronic viral hepatitis without cirrhosis (stage of fibrosis F1-F3 (Metavir) - 40 people, 2 group - patients diagnosed with cirrhosis in the outcome of viral hepatitis C Class A (Child-Pugh) -35 people and group 3 with diagnosis of cirrhosis Class B and C - 45 people. Results: thymosin-thymosin is more often found in the homozygous genotype of the inheritance of the angiotensinogen AT-6 gene (P <0.05) than in patients with chronic viral hepatitis. The inheritance of the homozygous genotype C/C of the AT-6 angiotensinogen gene is associated with an easier flow of chronic HCV infection (P <0.005) in the Kazakh population. The inheritance of the T allele in the group with compensated and decompensated cirrhosis is also statistically significant in comparison with the group of patients with chronic viral hepatitis C (P <0.05, P <0.005, respectively). Conclusion: An association was identified between of the gene angiotensin single nucleotide polymorphism located in (AT-6) promoter region -6 and fibrosis in chronic HCV infection.