Anodic oxidation of dithiane carboxylic acids: A rapid and mild way to access functionalized orthoesters

Anthony D. Garcia, Matthew C. Leech, Alessia Petti, Camille Denis, Iain C.A. Goodall, Adrian P. Dobbs, Kevin Lam

Research output: Contribution to journalArticle

Abstract

A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.

Original languageEnglish
Pages (from-to)4000-4005
Number of pages6
JournalOrganic Letters
Volume22
Issue number10
DOIs
Publication statusPublished - May 15 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Garcia, A. D., Leech, M. C., Petti, A., Denis, C., Goodall, I. C. A., Dobbs, A. P., & Lam, K. (2020). Anodic oxidation of dithiane carboxylic acids: A rapid and mild way to access functionalized orthoesters. Organic Letters, 22(10), 4000-4005. https://doi.org/10.1021/acs.orglett.0c01324