Anti-inflammatory effects and mechanism of berberine

J. Y. Jiang, D. S. Geng, T. Tursonjan, F. Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

AIM: To study the anti-inflammatory effects and the action mechanisms of berberine. METHODS: Leukocytes chemotaxis; chemiluminscence with respiratory burst of polymorphonuclears in vitro; microacidimetry of PLA2 activity; ultraviolet spectrometry of PGE2 in inflammatory footpad of rats. RESULTS: The Ber with 5 X 10-5. 5 X 10-4 mol · L-1 remarkably reduced the leukocytes chemotaxis induced by ZAP (zymosan actived plasma) in vitro and reduced its random motility in large content, inhibited luminol-dependent chemiluminscence (CL) produced by respiratory burst of rat polymorphonclears (PMNs). Ber also inhibited the CL produced by VitC - Cu2+, zymosan and release of hydrogen perxides with 5 X 10-4 5 X 10-5 mol · L-1 respectively. The phospholipase A2 (PLA2) activity of PMNs was decreased when incubated with Ber 1 h. Ber reduced the content of PGE2, in inflammatory tissue induced by carrageenin in vivo. CONCLUSIONS: The anti- inflammatory mechanism of Ber may involve in several paths.

Original languageEnglish
Pages (from-to)434-437
Number of pages4
JournalChinese Pharmacological Bulletin
Volume14
Issue number5
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Leukocyte Chemotaxis
Berberine
Zymosan
Respiratory Burst
Phospholipases A2
Dinoprostone
Anti-Inflammatory Agents
Luminol
Carrageenan
Hydrogen
Spectrum Analysis
In Vitro Techniques

Keywords

  • Chemiluminscence
  • Chemotaxis
  • Phospholipase A
  • Prostaglandin E

ASJC Scopus subject areas

  • Pharmacology

Cite this

Anti-inflammatory effects and mechanism of berberine. / Jiang, J. Y.; Geng, D. S.; Tursonjan, T.; Liu, F.

In: Chinese Pharmacological Bulletin, Vol. 14, No. 5, 1998, p. 434-437.

Research output: Contribution to journalArticle

Jiang, JY, Geng, DS, Tursonjan, T & Liu, F 1998, 'Anti-inflammatory effects and mechanism of berberine', Chinese Pharmacological Bulletin, vol. 14, no. 5, pp. 434-437.
Jiang, J. Y. ; Geng, D. S. ; Tursonjan, T. ; Liu, F. / Anti-inflammatory effects and mechanism of berberine. In: Chinese Pharmacological Bulletin. 1998 ; Vol. 14, No. 5. pp. 434-437.
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