Anti-inflammatory effects and mechanism of berberine

J. Y. Jiang, D. S. Geng, T. Tursonjan, F. Liu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


AIM: To study the anti-inflammatory effects and the action mechanisms of berberine. METHODS: Leukocytes chemotaxis; chemiluminscence with respiratory burst of polymorphonuclears in vitro; microacidimetry of PLA2 activity; ultraviolet spectrometry of PGE2 in inflammatory footpad of rats. RESULTS: The Ber with 5 X 10-5. 5 X 10-4 mol · L-1 remarkably reduced the leukocytes chemotaxis induced by ZAP (zymosan actived plasma) in vitro and reduced its random motility in large content, inhibited luminol-dependent chemiluminscence (CL) produced by respiratory burst of rat polymorphonclears (PMNs). Ber also inhibited the CL produced by VitC - Cu2+, zymosan and release of hydrogen perxides with 5 X 10-4 5 X 10-5 mol · L-1 respectively. The phospholipase A2 (PLA2) activity of PMNs was decreased when incubated with Ber 1 h. Ber reduced the content of PGE2, in inflammatory tissue induced by carrageenin in vivo. CONCLUSIONS: The anti- inflammatory mechanism of Ber may involve in several paths.

Original languageEnglish
Pages (from-to)434-437
Number of pages4
JournalChinese Pharmacological Bulletin
Issue number5
Publication statusPublished - Jan 1 1998


  • Chemiluminscence
  • Chemotaxis
  • Phospholipase A
  • Prostaglandin E

ASJC Scopus subject areas

  • Pharmacology

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