Antidote application: An educational system for treatment of common toxin overdose

Jon B. Long, Lou Chitkushev, Yingyuan Zhang, Guanglan Zhang, Vladimir Brusic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae. Current toxicological resources that support treatment decisions are broad in scope, time-consuming to read, or at times unavailable. Our review of current toxicological resources revealed a gap in their ability to provide expedient calculations and recommendations about appropriate course of treatment. To bridge the gap, we developed the Antidote Application (AA), a computational system that automatically provides patient-specific antidote treatment recommendations and individualized dose calculations. We implemented 27 algorithms that describe FDA (the US Food and Drug Administration) approved use and evidence-based practices found in primary literature for the treatment of common toxin exposure. The AA covers 29 antidotes recommended by Poison Control and toxicology experts, 19 poison classes and 31 poisons, which represent over 200 toxic entities. To the best of our knowledge, the AA is the first educational decision support system in toxicology that provides patient-specific treatment recommendations and drug dose calculations. The AA is publicly available at http://projects.methilab.org/antidote/.

Original languageEnglish
Title of host publicationACM-BCB 2017 - Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics
PublisherAssociation for Computing Machinery, Inc
Pages442-448
Number of pages7
ISBN (Electronic)9781450347228
DOIs
Publication statusPublished - Aug 20 2017
Event8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM-BCB 2017 - Boston, United States
Duration: Aug 20 2017Aug 23 2017

Publication series

NameACM-BCB 2017 - Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

Other

Other8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM-BCB 2017
CountryUnited States
CityBoston
Period8/20/178/23/17

Keywords

  • Decision support
  • Medical informatics
  • Poison control centers
  • Toxicity
  • Toxicology

ASJC Scopus subject areas

  • Software
  • Biomedical Engineering
  • Health Informatics
  • Computer Science Applications

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