ANTIMIC: A database of antimicrobial sequences

M. Brahmachary, S. P T Krishnan, J. L Y Koh, A. M. Khan, S. H. Seah, T. W. Tan, V. Brusic, V. B. Bajic

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Antimicrobial peptides (AMPs) are important components of the innate immune system of many species. These peptides are found in eukaryotes, including mammals, amphibians, insects and plants, as well as in prokaryotes. Other than having pathogen-lytic properties, these peptides have other activities like antitumor activity, mitogen activity, or they may act as signaling molecules. Their short length, fast and efficient action against microbes and low toxicity to mammals have made them potential candidates as peptide drugs. In many cases they are effective against pathogens that are resistant to conventional antibiotics. They can serve as natural templates for the design of novel antimicrobial drugs. Although there are vast amounts of data on natural AMPs, they are not available through one central resource. We have developed a comprehensive database (ANTIMIC, http://research.i2r.a-star.edu.sg/Templar/DB/ANTIMIC/) of known and putative AMPs, which contains ∼1700 of these peptides. The database is integrated with tools to facilitate efficient extraction of data and their analysis at molecular level, as well as search for new AMPs. These tools include BLAST, PDB structure viewer and the Antimic profile module.

Original languageEnglish
JournalNucleic Acids Research
Volume32
Issue numberDATABASE ISS.
Publication statusPublished - Jan 1 2004
Externally publishedYes

Fingerprint

Databases
Peptides
Mammals
Amphibians
Eukaryota
Mitogens
Pharmaceutical Preparations
Insects
Immune System
Anti-Bacterial Agents
Research

ASJC Scopus subject areas

  • Genetics

Cite this

Brahmachary, M., Krishnan, S. P. T., Koh, J. L. Y., Khan, A. M., Seah, S. H., Tan, T. W., ... Bajic, V. B. (2004). ANTIMIC: A database of antimicrobial sequences. Nucleic Acids Research, 32(DATABASE ISS.).

ANTIMIC : A database of antimicrobial sequences. / Brahmachary, M.; Krishnan, S. P T; Koh, J. L Y; Khan, A. M.; Seah, S. H.; Tan, T. W.; Brusic, V.; Bajic, V. B.

In: Nucleic Acids Research, Vol. 32, No. DATABASE ISS., 01.01.2004.

Research output: Contribution to journalArticle

Brahmachary, M, Krishnan, SPT, Koh, JLY, Khan, AM, Seah, SH, Tan, TW, Brusic, V & Bajic, VB 2004, 'ANTIMIC: A database of antimicrobial sequences', Nucleic Acids Research, vol. 32, no. DATABASE ISS..
Brahmachary M, Krishnan SPT, Koh JLY, Khan AM, Seah SH, Tan TW et al. ANTIMIC: A database of antimicrobial sequences. Nucleic Acids Research. 2004 Jan 1;32(DATABASE ISS.).
Brahmachary, M. ; Krishnan, S. P T ; Koh, J. L Y ; Khan, A. M. ; Seah, S. H. ; Tan, T. W. ; Brusic, V. ; Bajic, V. B. / ANTIMIC : A database of antimicrobial sequences. In: Nucleic Acids Research. 2004 ; Vol. 32, No. DATABASE ISS.
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