Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.
- antimicrobial peptides
- biological activity
- micromycetes of the Emericellopsis genus
- multiple resistance
- pathogenic fungi
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology