Abstract
Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 145-151 |
| Number of pages | 7 |
| Journal | Applied Biochemistry and Microbiology |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 1 2019 |
| Externally published | Yes |
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Keywords
- antimicrobial peptides
- biological activity
- micromycetes of the Emericellopsis genus
- multiple resistance
- pathogenic fungi
- peptaibols
ASJC Scopus subject areas
- Biochemistry
- Applied Microbiology and Biotechnology
Cite this
Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina : Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi. / Baranova, A. A.; Rogozhin, E. A.; Georgieva, M. L.; Bilanenko, E. N.; Kul’ko, A. B.; Yakushev, A. V.; Alferova, V. A.; Sadykova, V. S.
In: Applied Biochemistry and Microbiology, Vol. 55, No. 2, 01.03.2019, p. 145-151.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina
T2 - Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi
AU - Baranova, A. A.
AU - Rogozhin, E. A.
AU - Georgieva, M. L.
AU - Bilanenko, E. N.
AU - Kul’ko, A. B.
AU - Yakushev, A. V.
AU - Alferova, V. A.
AU - Sadykova, V. S.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.
AB - Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.
KW - antimicrobial peptides
KW - biological activity
KW - micromycetes of the Emericellopsis genus
KW - multiple resistance
KW - pathogenic fungi
KW - peptaibols
UR - http://www.scopus.com/inward/record.url?scp=85066249160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066249160&partnerID=8YFLogxK
U2 - 10.1134/S0003683819020030
DO - 10.1134/S0003683819020030
M3 - Article
AN - SCOPUS:85066249160
VL - 55
SP - 145
EP - 151
JO - Applied Biochemistry and Microbiology
JF - Applied Biochemistry and Microbiology
SN - 0003-6838
IS - 2
ER -