Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina: Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi

A. A. Baranova; E. A. Rogozhin; M. L. Georgieva; E. N. Bilanenko; A. B. Kul’ko; A. V. Yakushev; V. A. Alferova; V. S. Sadykova

doi:10.1134/S0003683819020030

Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina: Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi

A. A. Baranova, E. A. Rogozhin, M. L. Georgieva, E. N. Bilanenko, A. B. Kul’ko, A. V. Yakushev, V. A. Alferova, V. S. Sadykova

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.

Original language	English
Pages (from-to)	145-151
Number of pages	7
Journal	Applied Biochemistry and Microbiology
Volume	55
Issue number	2
DOIs	https://doi.org/10.1134/S0003683819020030
Publication status	Published - Mar 1 2019
Externally published	Yes

Keywords

antimicrobial peptides
biological activity
micromycetes of the Emericellopsis genus
multiple resistance
pathogenic fungi
peptaibols

ASJC Scopus subject areas

Biochemistry
Applied Microbiology and Biotechnology

Access to Document

10.1134/S0003683819020030

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Baranova, A. A., Rogozhin, E. A., Georgieva, M. L., Bilanenko, E. N., Kul’ko, A. B., Yakushev, A. V., Alferova, V. A., & Sadykova, V. S. (2019). Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina: Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi. Applied Biochemistry and Microbiology, 55(2), 145-151. https://doi.org/10.1134/S0003683819020030

Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina : Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi. / Baranova, A. A.; Rogozhin, E. A.; Georgieva, M. L.; Bilanenko, E. N.; Kul’ko, A. B.; Yakushev, A. V.; Alferova, V. A.; Sadykova, V. S.

In: Applied Biochemistry and Microbiology, Vol. 55, No. 2, 01.03.2019, p. 145-151.

Research output: Contribution to journal › Article › peer-review

Baranova, AA, Rogozhin, EA, Georgieva, ML, Bilanenko, EN, Kul’ko, AB, Yakushev, AV, Alferova, VA & Sadykova, VS 2019, 'Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina: Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi', Applied Biochemistry and Microbiology, vol. 55, no. 2, pp. 145-151. https://doi.org/10.1134/S0003683819020030

Baranova, A. A. ; Rogozhin, E. A. ; Georgieva, M. L. ; Bilanenko, E. N. ; Kul’ko, A. B. ; Yakushev, A. V. ; Alferova, V. A. ; Sadykova, V. S. / Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina : Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi. In: Applied Biochemistry and Microbiology. 2019 ; Vol. 55, No. 2. pp. 145-151.

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abstract = "Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.",

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AB - Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.

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