Antimicrobial Peptides Produced by Alkaliphilic Fungi Emericellopsis alkalina: Biosynthesis and Biological Activity Against Pathogenic Multidrug-Resistant Fungi

A. A. Baranova, E. A. Rogozhin, M. L. Georgieva, E. N. Bilanenko, A. B. Kul’ko, A. V. Yakushev, V. A. Alferova, V. S. Sadykova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Abstract: The ability of 22 strains of the Emericellopsis alkalina species to synthesize the antimicrobial peptaiboles A118-35, A118-36, and A118-37 with antifungal activity was studied. The ability to synthesize peptaibols is typical for 72% of the studied strains of the species. It was established that peptaibol production is a strain-specific feature and depends on the cultivation conditions and the concentration of sugars and carbon sources. The isolated peptaibol A118-37 was active against opportunistic Candida albicans yeast and Apergillus niger mold fungus, as well as against clinical fungal isolates of mycosis pathogens with multiple resistance.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalApplied Biochemistry and Microbiology
Volume55
Issue number2
DOIs
Publication statusPublished - Mar 1 2019
Externally publishedYes

Keywords

  • antimicrobial peptides
  • biological activity
  • micromycetes of the Emericellopsis genus
  • multiple resistance
  • pathogenic fungi
  • peptaibols

ASJC Scopus subject areas

  • Biochemistry
  • Applied Microbiology and Biotechnology

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