Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Shynggys Sergazy; Anastassiya Vetrova; Ilkay Erdogan Orhan; Fatma Sezer Senol Deniz; Ahmet Kahraman; Jian Ye Zhang; Mohamad Aljofan

doi:10.2144/fsoa-2021-0109

Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Shynggys Sergazy, Anastassiya Vetrova, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Ahmet Kahraman, Jian Ye Zhang, Mohamad Aljofan

Nazarbayev University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.

Original language	English
Article number	FSO775
Journal	Future Science OA
Volume	8
Issue number	2
DOIs	https://doi.org/10.2144/fsoa-2021-0109
Publication status	Published - Feb 2022

Keywords

anticancer
antiproliferative
breast cancer
cytotoxicity
Erodium
Geraniaceae
Geranium

ASJC Scopus subject areas

Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2144/fsoa-2021-0109

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title = "Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines",

abstract = "Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.",

keywords = "anticancer, antiproliferative, breast cancer, cytotoxicity, Erodium, Geraniaceae, Geranium",

author = "Shynggys Sergazy and Anastassiya Vetrova and Orhan, {Ilkay Erdogan} and {Senol Deniz}, {Fatma Sezer} and Ahmet Kahraman and Zhang, {Jian Ye} and Mohamad Aljofan",

note = "Funding Information: This work was supported through Social Policy Research Grant; PI-M.A provided by Nazarbayev University School of Medicine (NUSOM) and by the Nazarbayev University Collaborative Research Program 2021-2023 (Award no. OPCRP2021006). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 Mohamad Aljofan.",

year = "2022",

month = feb,

doi = "10.2144/fsoa-2021-0109",

language = "English",

volume = "8",

journal = "Future Science OA",

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AU - Sergazy, Shynggys

AU - Vetrova, Anastassiya

AU - Orhan, Ilkay Erdogan

AU - Senol Deniz, Fatma Sezer

AU - Kahraman, Ahmet

AU - Zhang, Jian Ye

AU - Aljofan, Mohamad

N1 - Funding Information: This work was supported through Social Policy Research Grant; PI-M.A provided by Nazarbayev University School of Medicine (NUSOM) and by the Nazarbayev University Collaborative Research Program 2021-2023 (Award no. OPCRP2021006). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2021 Mohamad Aljofan.

PY - 2022/2

Y1 - 2022/2

N2 - Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.

AB - Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.

KW - anticancer

KW - antiproliferative

KW - breast cancer

KW - cytotoxicity

KW - Erodium

KW - Geraniaceae

KW - Geranium

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Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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