Antiviral Resistance of Splenocytes in Aged Mice

Ewa Zaczyńska, Jolanta Artym, Maja Kocięba, Timo Burster, Marian Kruzel, Maria Paprocka, Michał Zimecki

Research output: Contribution to journalArticle

Abstract

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalPolish Journal of Microbiology
Volume66
Issue number1
DOIs
Publication statusPublished - Mar 30 2017
Externally publishedYes

Keywords

  • Aging/immunology
  • Animals
  • Antiviral Agents
  • Cattle
  • Cells, Cultured
  • Encephalomyocarditis virus/drug effects
  • Lactoferrin/pharmacology
  • Mice
  • Mice, Inbred CBA
  • Recombinant Proteins
  • Spleen/cytology

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  • Cite this

    Zaczyńska, E., Artym, J., Kocięba, M., Burster, T., Kruzel, M., Paprocka, M., & Zimecki, M. (2017). Antiviral Resistance of Splenocytes in Aged Mice. Polish Journal of Microbiology, 66(1), 131-134. https://doi.org/10.5604/17331331.1235002