Apoptosis in autoimmune and non-autoimmune thyroid disease.

M. Ludgate, B. Jasani

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The elimination of autoreactive T cells in the thymus involves the process of programmed cell death. Animal model studies, using the lpr and gld strains of mice, have identified FAS receptor (FAS) and FAS ligand (FAS-L) as important components of this mechanism. Whether FAS and FAS-L are also implicated in the autoimmune destruction of a target organ, such as the thyroid, remain hypothetical. An accompanying paper in this issue has addressed the question by FACS and immunocytochemical analysis of FAS expression and apoptosis in thyrocytes grown in culture and in intact thyroid tissues obtained from Hashimoto's thyroiditis, multinodular goitre and Graves' disease. The overall results suggest that the degree of FAS expression on target cells may determine their sensitivity to T-cell mediated cytotoxicity in the absence of perforin or granzyme directed apoptosis mechanisms.

Original languageEnglish
Pages (from-to)123-124
Number of pages2
JournalJournal of Pathology
Volume182
Issue number2
Publication statusPublished - Jun 1997
Externally publishedYes

Fingerprint

Thyroid Diseases
Thyroid Gland
Apoptosis
Ligands
T-Lymphocytes
Granzymes
Perforin
Hashimoto Disease
Graves Disease
Goiter
Thymus Gland
Cell Death
Animal Models
Thyroid Epithelial Cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ludgate, M., & Jasani, B. (1997). Apoptosis in autoimmune and non-autoimmune thyroid disease. Journal of Pathology, 182(2), 123-124.

Apoptosis in autoimmune and non-autoimmune thyroid disease. / Ludgate, M.; Jasani, B.

In: Journal of Pathology, Vol. 182, No. 2, 06.1997, p. 123-124.

Research output: Contribution to journalArticle

Ludgate, M & Jasani, B 1997, 'Apoptosis in autoimmune and non-autoimmune thyroid disease.', Journal of Pathology, vol. 182, no. 2, pp. 123-124.
Ludgate, M. ; Jasani, B. / Apoptosis in autoimmune and non-autoimmune thyroid disease. In: Journal of Pathology. 1997 ; Vol. 182, No. 2. pp. 123-124.
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