Apoptosis in autoimmune and non-autoimmune thyroid disease.

M. Ludgate, B. Jasani

Research output: Contribution to journalEditorialpeer-review

14 Citations (Scopus)


The elimination of autoreactive T cells in the thymus involves the process of programmed cell death. Animal model studies, using the lpr and gld strains of mice, have identified FAS receptor (FAS) and FAS ligand (FAS-L) as important components of this mechanism. Whether FAS and FAS-L are also implicated in the autoimmune destruction of a target organ, such as the thyroid, remain hypothetical. An accompanying paper in this issue has addressed the question by FACS and immunocytochemical analysis of FAS expression and apoptosis in thyrocytes grown in culture and in intact thyroid tissues obtained from Hashimoto's thyroiditis, multinodular goitre and Graves' disease. The overall results suggest that the degree of FAS expression on target cells may determine their sensitivity to T-cell mediated cytotoxicity in the absence of perforin or granzyme directed apoptosis mechanisms.

Original languageEnglish
Pages (from-to)123-124
Number of pages2
JournalThe Journal of pathology
Issue number2
Publication statusPublished - Jun 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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