Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults

Zelalem Temesgen, Francesca Cainelli, Eric M. Poeschla, Stacey AR Vlahakis, Sandro Vento

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.

Original languageEnglish
Pages (from-to)496-507
Number of pages12
JournalLancet Infectious Diseases
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 2006
Externally publishedYes

Fingerprint

Salvage Therapy
HIV
Mortality
Highly Active Antiretroviral Therapy
Therapeutics
Morbidity

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults. / Temesgen, Zelalem; Cainelli, Francesca; Poeschla, Eric M.; Vlahakis, Stacey AR; Vento, Sandro.

In: Lancet Infectious Diseases, Vol. 6, No. 8, 08.2006, p. 496-507.

Research output: Contribution to journalReview article

@article{abd447b818d54f9fb088f1ddcebbf49c,
title = "Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults",
abstract = "Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.",
author = "Zelalem Temesgen and Francesca Cainelli and Poeschla, {Eric M.} and Vlahakis, {Stacey AR} and Sandro Vento",
year = "2006",
month = "8",
doi = "10.1016/S1473-3099(06)70550-3",
language = "English",
volume = "6",
pages = "496--507",
journal = "The Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "Lancet Publishing Group",
number = "8",

}

TY - JOUR

T1 - Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults

AU - Temesgen, Zelalem

AU - Cainelli, Francesca

AU - Poeschla, Eric M.

AU - Vlahakis, Stacey AR

AU - Vento, Sandro

PY - 2006/8

Y1 - 2006/8

N2 - Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.

AB - Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.

UR - http://www.scopus.com/inward/record.url?scp=33746266719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746266719&partnerID=8YFLogxK

U2 - 10.1016/S1473-3099(06)70550-3

DO - 10.1016/S1473-3099(06)70550-3

M3 - Review article

VL - 6

SP - 496

EP - 507

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

SN - 1473-3099

IS - 8

ER -