Abstract
Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
| Original language | English |
|---|---|
| Pages (from-to) | 496-507 |
| Number of pages | 12 |
| Journal | Lancet Infectious Diseases |
| Volume | 6 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Infectious Diseases
Cite this
Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults. / Temesgen, Zelalem; Cainelli, Francesca; Poeschla, Eric M.; Vlahakis, Stacey AR; Vento, Sandro.
In: Lancet Infectious Diseases, Vol. 6, No. 8, 08.2006, p. 496-507.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults
AU - Temesgen, Zelalem
AU - Cainelli, Francesca
AU - Poeschla, Eric M.
AU - Vlahakis, Stacey AR
AU - Vento, Sandro
PY - 2006/8
Y1 - 2006/8
N2 - Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
AB - Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
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UR - http://www.scopus.com/inward/citedby.url?scp=33746266719&partnerID=8YFLogxK
U2 - 10.1016/S1473-3099(06)70550-3
DO - 10.1016/S1473-3099(06)70550-3
M3 - Review article
VL - 6
SP - 496
EP - 507
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
SN - 1473-3099
IS - 8
ER -