TY - JOUR
T1 - Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults
AU - Temesgen, Zelalem
AU - Cainelli, Francesca
AU - Poeschla, Eric M.
AU - Vlahakis, Stacey AR
AU - Vento, Sandro
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
AB - Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
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U2 - 10.1016/S1473-3099(06)70550-3
DO - 10.1016/S1473-3099(06)70550-3
M3 - Review article
C2 - 16870528
AN - SCOPUS:33746266719
VL - 6
SP - 496
EP - 507
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
SN - 1473-3099
IS - 8
ER -