Artificial genetic polymers against human pathologies

Gleb S. Ivanov; Vyacheslav G. Tribulovich; Nikolay B. Pestov; Temitope I. David; Abdul Saleem Amoah; Tatyana V. Korneenko; Nikolai A. Barlev

doi:10.1186/s13062-022-00353-7

Artificial genetic polymers against human pathologies

Gleb S. Ivanov
, Vyacheslav G. Tribulovich
, Nikolay B. Pestov
, Temitope I. David
, Abdul Saleem Amoah
, Tatyana V. Korneenko
, Nikolai A. Barlev

RAS - Institute of Cytology
St. Petersburg State Institute of Technology
RAS - Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products
Moscow Institute of Physics and Technology
Russian Academy of Sciences
Russian Academy of Medical Sciences - Institute of Biomedical Chemistry
Nazarbayev University

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

Original language	English
Article number	39
Journal	Biology Direct
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s13062-022-00353-7
Publication status	Published - Dec 2022
Externally published	Yes

Keywords

Locked nucleic acids
Peptide nucleic acids
Xenonucleic acids

ASJC Scopus subject areas

Immunology
Ecology, Evolution, Behavior and Systematics
Modelling and Simulation
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences
Applied Mathematics

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10.1186/s13062-022-00353-7

Cite this

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title = "Artificial genetic polymers against human pathologies",

abstract = "Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.",

keywords = "Locked nucleic acids, Peptide nucleic acids, Xenonucleic acids",

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note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s13062-022-00353-7",

language = "English",

volume = "17",

journal = "Biology Direct",

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number = "1",

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TY - JOUR

T1 - Artificial genetic polymers against human pathologies

AU - Ivanov, Gleb S.

AU - Tribulovich, Vyacheslav G.

AU - Pestov, Nikolay B.

AU - David, Temitope I.

AU - Amoah, Abdul Saleem

AU - Korneenko, Tatyana V.

AU - Barlev, Nikolai A.

PY - 2022/12

Y1 - 2022/12

N2 - Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

AB - Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

KW - Locked nucleic acids

KW - Peptide nucleic acids

KW - Xenonucleic acids

UR - https://www.scopus.com/pages/publications/85143548222

UR - https://www.scopus.com/pages/publications/85143548222#tab=citedBy

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DO - 10.1186/s13062-022-00353-7

M3 - Review article

C2 - 36474260

AN - SCOPUS:85143548222

SN - 1745-6150

VL - 17

JO - Biology Direct

JF - Biology Direct

IS - 1

M1 - 39

ER -

Artificial genetic polymers against human pathologies

Abstract

Keywords

ASJC Scopus subject areas

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