Association between C677T/MTHFR genotype and homocysteine concentration in a Kazakh population

Ainur Akilzhanova, Noboru Takamura, Yosuke Kusano, Ludmila Karazhanova, Shunichi Yamashita, Hiroshi Saito, Kiyoshi Aoyagi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We recently suggested that due to insufficient intake of vegetables, low folate status and mild homocysteinemia might exist in the Kazakh population. To clarify the determinants of homocysteine concentrations among this population, we determined concentrations of serum folate, albumin, creatinine, vitamin B12, and the C677T/ MTHFR genotype in 110 Kazakh individuals and compared these with plasma total homocysteine. In Kazakh, after adjustment for age and sex, folate was correlated with plasma total homocysteine, whereas concentrations in those with the TT genotype was almost twice as high as in those with the CC and CT genotypes (19.7±1.8 mol/L vs. 10.7±0.5 mol/L, p<0.001). Our results suggest that the C677T/MTHFR genotype is associated with homocysteine concentrations in this population and this association might be affected by other factors, such as folate status.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalAsia Pacific Journal of Clinical Nutrition
Volume17
Issue number2
Publication statusPublished - Jun 2008
Externally publishedYes

Keywords

  • 5,10-Methylenetetrahydrofolate reductase
  • Folate
  • Homocysteine
  • Kazakh

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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