TY - JOUR
T1 - Association Between Serum Leptin Level and Mortality in Kidney Transplant Recipients
AU - Molnar, Miklos Z.
AU - Nagy, Kristof
AU - Remport, Adam
AU - Gaipov, Abduzhappar
AU - Fülöp, Tibor
AU - Czira, Maria E.
AU - Kovesdy, Csaba P.
AU - Mucsi, Istvan
AU - Mathe, Zoltan
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective Leptin is a hormone made by adipocytes and associated with hypertension, inflammation, and coronary artery disease. Low serum leptin level was associated with higher risk of death in patients with advanced chronic kidney disease. Little is known about the association of serum leptin with outcomes in kidney transplant recipients. Design Prospective prevalent cohort. Setting and Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data of 979 prevalent kidney transplant recipients. Associations between serum leptin level and death with a functioning graft, all-cause death, and death-censored graft loss over a 6-year follow-up period were examined in survival models. Results Serum leptin levels showed moderate negative correlation with eGFR (R = −0.21, P < .001) and positive correlations with BMI (R = 0.48, P < .001) and C-reactive protein (R = 0.20, P < .001). Each 10 ng/mL higher serum leptin level was associated with 7% lower risk of death with functioning graft (hazard ratio [HR] (95% confidence interval [CI]), 0.93 (0.87-0.99)), and this association persisted after adjustment for confounders: HR (95% CI), 0.90 (0.82-0.99). Similar associations were found with all-cause death as outcome. The association between serum leptin level and risk of graft loss was nonlinear, and only low serum leptin level was associated with higher risk of graft loss. Conclusions In prevalent kidney transplant recipients, lower serum leptin was an independent predictor of death.
AB - Objective Leptin is a hormone made by adipocytes and associated with hypertension, inflammation, and coronary artery disease. Low serum leptin level was associated with higher risk of death in patients with advanced chronic kidney disease. Little is known about the association of serum leptin with outcomes in kidney transplant recipients. Design Prospective prevalent cohort. Setting and Subject We collected sociodemographic and clinical parameters, medical and transplant history, and laboratory data of 979 prevalent kidney transplant recipients. Associations between serum leptin level and death with a functioning graft, all-cause death, and death-censored graft loss over a 6-year follow-up period were examined in survival models. Results Serum leptin levels showed moderate negative correlation with eGFR (R = −0.21, P < .001) and positive correlations with BMI (R = 0.48, P < .001) and C-reactive protein (R = 0.20, P < .001). Each 10 ng/mL higher serum leptin level was associated with 7% lower risk of death with functioning graft (hazard ratio [HR] (95% confidence interval [CI]), 0.93 (0.87-0.99)), and this association persisted after adjustment for confounders: HR (95% CI), 0.90 (0.82-0.99). Similar associations were found with all-cause death as outcome. The association between serum leptin level and risk of graft loss was nonlinear, and only low serum leptin level was associated with higher risk of graft loss. Conclusions In prevalent kidney transplant recipients, lower serum leptin was an independent predictor of death.
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U2 - 10.1053/j.jrn.2016.08.008
DO - 10.1053/j.jrn.2016.08.008
M3 - Article
C2 - 27666945
AN - SCOPUS:84994441028
VL - 27
SP - 53
EP - 61
JO - Journal of Renal Nutrition
JF - Journal of Renal Nutrition
SN - 1051-2276
IS - 1
ER -