TY - JOUR
T1 - Association of genetic variations in the vitamin D pathway with susceptibility to tuberculosis in Kazakhstan
AU - Sadykov, Mukhtar
AU - Azizan, Azliyati
AU - Kozhamkulov, Ulan
AU - Akilzhanova, Ainur
AU - Yerezhepov, Dauren
AU - Salfinger, Max
AU - Chan, Chee Kai
N1 - Funding Information:
We like to acknowledge that the SNP genotyping was done with the support and the use of the SNP array developed by Fitgenes Pty Ltd, Melbourne Australia. We are grateful to Columbia University Global Health Research Center of Central Asia, Almaty and National TB Center, Almaty for organizational support of study participant recruitment.
Funding Information:
This work was supported by the Nazarbayev University School of Medicine Social Policy Grant 2016 and by the Ministry of Education and Science of the Republic of Kazakhstan (Grants No. AP05134737, 0111RK00442).
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Tuberculosis (TB) poses an important health challenge and a significant economic burden for Kazakhstan and in Central Asia. Recent findings show a number of immunological related processes and host Mycobacterium tuberculosis defense are impacted by a variety of genes of the human host including those that play a part in the vitamin D metabolism. We investigated the genetic variation of genes in the vitamin D metabolic pathway of a cohort 50 TB cases in Kazakhstan and compared them to 34 controls living in the same household with someone infected with TB. We specifically analyzed 11 SNPs belonging to the following genes: DHCR7, CYP2R1, GC-1, CYP24A1, CYP27A1, CYP27B1, VDR and TNFα. These genes play a number of different roles including synthesis, activation, delivery and binding of the activated vitamin D. Our preliminary results indicate significant association of VDR (vitamin D receptor) SNPs (rs1544410, BsmI, with OR = 0.425, CI 0.221–0.816, p = 0.009 and rs731236, TaqI with OR = 0.443, CI 0.228–0.859, p = 0.015) and CYP24A1 (rs6013897 with OR = 0.436, CI 0.191–0.996, p = 0.045) with TB. Interaction of genetic variation of VDR and CYP24A1 may impact susceptibility to TB. The findings provided initial clues to understand individual genetic differences in relation to susceptibility and protection to TB.
AB - Tuberculosis (TB) poses an important health challenge and a significant economic burden for Kazakhstan and in Central Asia. Recent findings show a number of immunological related processes and host Mycobacterium tuberculosis defense are impacted by a variety of genes of the human host including those that play a part in the vitamin D metabolism. We investigated the genetic variation of genes in the vitamin D metabolic pathway of a cohort 50 TB cases in Kazakhstan and compared them to 34 controls living in the same household with someone infected with TB. We specifically analyzed 11 SNPs belonging to the following genes: DHCR7, CYP2R1, GC-1, CYP24A1, CYP27A1, CYP27B1, VDR and TNFα. These genes play a number of different roles including synthesis, activation, delivery and binding of the activated vitamin D. Our preliminary results indicate significant association of VDR (vitamin D receptor) SNPs (rs1544410, BsmI, with OR = 0.425, CI 0.221–0.816, p = 0.009 and rs731236, TaqI with OR = 0.443, CI 0.228–0.859, p = 0.015) and CYP24A1 (rs6013897 with OR = 0.436, CI 0.191–0.996, p = 0.045) with TB. Interaction of genetic variation of VDR and CYP24A1 may impact susceptibility to TB. The findings provided initial clues to understand individual genetic differences in relation to susceptibility and protection to TB.
KW - Kazakhstan
KW - SNP
KW - Tuberculosis
KW - VDR
KW - Vitamin D
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U2 - 10.1007/s11033-020-05255-3
DO - 10.1007/s11033-020-05255-3
M3 - Article
C2 - 31933264
AN - SCOPUS:85078061111
VL - 47
SP - 1659
EP - 1666
JO - Molecular Biology Reports
JF - Molecular Biology Reports
SN - 0301-4851
IS - 3
ER -