Bacterial resistance in the intensive care unit of developing countries: Report from a tertiary hospital in Kazakhstan

Dmitriy Viderman, Evgeni Brotfain, Yekaterina Khamzina, Gulnara Kapanova, Agzam Zhumadilov, Dimitri Poddighe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: The aim of this study was to describe the patterns of antimicrobial resistance (AMR) of bacterial isolates causing hospital-acquired infections (HAIs) in the intensive care unit (ICU) of a tertiary hospital in Kazakhstan. Methods: This was a retrospective analysis of AMR in the ICU of the National Research Center for Oncology and Transplantation (Astana, Kazakhstan) during the year 2015. Results: During the study period, 546 patients were admitted to the ICU, of whom 135 (24.7%) developed at least one HAI. Most HAIs caused by Gram-positive bacteria were due to Enterococcus faecalis, which were resistant to aminoglycosides in >70% cases. Gram-negative bacteria were isolated in ca. 50% of cases, thus representing the greatest burden of HAIs. Very high resistance rates to ceftriaxone, cefotaxime and cefuroxime were observed. Moreover, Pseudomonas aeruginosa and Acinetobacter baumannii were resistant to carbapenems in <20% and in ca. 45% of cases, respectively. Conclusion: This study demonstrates the urgent need to implement more rational use of antimicrobials in Kazakhstan, which can be done only by establishing a proactive surveillance system along with an appropriate infection control programme.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalJournal of Global Antimicrobial Resistance
Volume17
DOIs
Publication statusPublished - Jun 1 2019

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Kazakhstan
Cross Infection
Tertiary Care Centers
Developing Countries
Intensive Care Units
Acinetobacter baumannii
Cefuroxime
Carbapenems
Cefotaxime
Ceftriaxone
Enterococcus faecalis
Gram-Positive Bacteria
Aminoglycosides
Infection Control
Gram-Negative Bacteria
Pseudomonas aeruginosa
Transplantation
Research

Keywords

  • Antimicrobial resistance
  • Carbapenems
  • Developing countries
  • Hospital-acquired infection
  • Intensive care unit

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

Cite this

Bacterial resistance in the intensive care unit of developing countries : Report from a tertiary hospital in Kazakhstan. / Viderman, Dmitriy; Brotfain, Evgeni; Khamzina, Yekaterina; Kapanova, Gulnara; Zhumadilov, Agzam; Poddighe, Dimitri.

In: Journal of Global Antimicrobial Resistance, Vol. 17, 01.06.2019, p. 35-38.

Research output: Contribution to journalArticle

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