Activities per year
Abstract
The development of efficient methodologies for production of amines attracts significant attention from synthetic chemists, because amines serve as essential building blocks in the synthesis of many pharmaceuticals, natural products, and agrochemicals. In this regard, deoxygenative reduction of amides to amines by means of transition-metal-catalyzed hydrogenation, hydrosilylation, and hydroboration reactions represents an attractive alternative to conventional wasteful techniques based on stoichiometric reductions of the corresponding amides and imines, and reductive amination of aldehydes with metal hydride reagents. The relatively low electrophilicity of the amide carbonyl group makes this transformation more challenging compared to reduction of other carbonyl compounds, and the majority of the reported catalytic systems employ precious metals such as platinum, rhodium, iridium, and ruthenium. Despite the application of more abundant and environmentally benign base metal (Mn, Fe, Co, and Ni) complexes for deoxygenative reduction of amides have been developed to a lesser extent, such catalytic systems are of great importance. This review is focused on the current achievements in the base-metal-catalyzed deoxygenative hydrogenation, hydrosilylation, and hydroboration of amides to amines. Special attention is paid to the design of base metal catalysts and the mechanisms of such catalytic transformations.
Original language | English |
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Article number | 10.3390/catal9060490 |
Number of pages | 26 |
Journal | Catalysts |
Volume | 9 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2019 |
Keywords
- Amides
- Amines
- Base metals
- Homogeneous catalysis
- Hydroboration
- Hydrogenation
- Hydrosilylation
- Reduction
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
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Brock University
Andrey Khalimon (Visiting researcher)
May 27 2018 → Jun 29 2018Activity: Visiting types › Visiting an external research institution
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2018 NU Research Day
Andrey Khalimon (Invited speaker)
Oct 18 2018Activity: Participating in event › Participation in conference
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Brock University
Andrey Khalimon (Visiting researcher)
May 26 2017 → Jun 17 2017Activity: Visiting types › Visiting an external research institution