Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling

Tadashi Fukunaka, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a mathematical model using only the first Kapur function, and it was consistent with experimental data satisfactorily. As the shape of the function was much different from that of inorganic compound and peculiar to API, a cubic function with respect to particle diameter was defined newly and well fitted to the experimental data. The function was also found to be affected by the operating parameters as the grinding gas pressure, the charge weight of raw material and the linear velocity at the grinding nozzle. According to the assessments of the breakage and the selection functions derived from the first Kapur function, it was found that the grinding mechanism of Ethenzamide particles was related with particle attrition mainly.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume311
Issue number1-2
DOIs
Publication statusPublished - Mar 27 2006

Keywords

  • Batch grinding
  • Ethenzamide
  • Fluidized-bed jet-mill
  • Kinetics
  • Mathematical model

ASJC Scopus subject areas

  • Pharmaceutical Science

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