Abstract
Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a mathematical model using only the first Kapur function, and it was consistent with experimental data satisfactorily. As the shape of the function was much different from that of inorganic compound and peculiar to API, a cubic function with respect to particle diameter was defined newly and well fitted to the experimental data. The function was also found to be affected by the operating parameters as the grinding gas pressure, the charge weight of raw material and the linear velocity at the grinding nozzle. According to the assessments of the breakage and the selection functions derived from the first Kapur function, it was found that the grinding mechanism of Ethenzamide particles was related with particle attrition mainly.
| Original language | English |
|---|---|
| Pages (from-to) | 89-96 |
| Number of pages | 8 |
| Journal | International Journal of Pharmaceutics |
| Volume | 311 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Mar 27 2006 |
| Externally published | Yes |
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Keywords
- Batch grinding
- Ethenzamide
- Fluidized-bed jet-mill
- Kinetics
- Mathematical model
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling. / Fukunaka, Tadashi; Golman, Boris; Shinohara, Kunio.
In: International Journal of Pharmaceutics, Vol. 311, No. 1-2, 27.03.2006, p. 89-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling
AU - Fukunaka, Tadashi
AU - Golman, Boris
AU - Shinohara, Kunio
PY - 2006/3/27
Y1 - 2006/3/27
N2 - Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a mathematical model using only the first Kapur function, and it was consistent with experimental data satisfactorily. As the shape of the function was much different from that of inorganic compound and peculiar to API, a cubic function with respect to particle diameter was defined newly and well fitted to the experimental data. The function was also found to be affected by the operating parameters as the grinding gas pressure, the charge weight of raw material and the linear velocity at the grinding nozzle. According to the assessments of the breakage and the selection functions derived from the first Kapur function, it was found that the grinding mechanism of Ethenzamide particles was related with particle attrition mainly.
AB - Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a mathematical model using only the first Kapur function, and it was consistent with experimental data satisfactorily. As the shape of the function was much different from that of inorganic compound and peculiar to API, a cubic function with respect to particle diameter was defined newly and well fitted to the experimental data. The function was also found to be affected by the operating parameters as the grinding gas pressure, the charge weight of raw material and the linear velocity at the grinding nozzle. According to the assessments of the breakage and the selection functions derived from the first Kapur function, it was found that the grinding mechanism of Ethenzamide particles was related with particle attrition mainly.
KW - Batch grinding
KW - Ethenzamide
KW - Fluidized-bed jet-mill
KW - Kinetics
KW - Mathematical model
UR - http://www.scopus.com/inward/record.url?scp=33644634018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644634018&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2005.12.018
DO - 10.1016/j.ijpharm.2005.12.018
M3 - Article
VL - 311
SP - 89
EP - 96
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -