Bench-Stable Cobalt Pre-Catalysts for Mild Hydrosilative Reduction of Tertiary Amides to Amines and Beyond

Alibek Nurseiit; Jaysan Janabel; Kristina Gudun; Aishabibi Kassymbek; Medet Segizbayev; Tulegen Seilkhanov; Andrey Khalimon

doi:10.1002/cctc.201801605

Bench-Stable Cobalt Pre-Catalysts for Mild Hydrosilative Reduction of Tertiary Amides to Amines and Beyond

Alibek Nurseiit, Jaysan Janabel, Kristina Gudun, Aishabibi Kassymbek, Medet Segizbayev, Tulegen Seilkhanov, Andrey Khalimon

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The readily synthesized and bench‐stable cobalt dichloride complex (dpephos)CoCl₂ is employed as a pre‐catalyst for a diversity of silane additions to unsaturated organic molecules, including the normally challenging reduction of amides to amines. With regard to hydrosilative reduction of amides even more effective and activator free catalytic systems can be generated from the bench‐stable, commercially available Co(acac)₂ and Co(OAc)₂ with dpephos and PPh₃ ligands. These systems operate under mild conditions (<100 °C), with many examples of room temperature transformations, presenting a first example of mild cobalt‐catalyzed hydrosilylation of amides

Original language	English
Article number	10.1002/cctc.201801605
Pages (from-to)	790-798
Number of pages	9
Journal	ChemCatChem
Volume	11
Issue number	2
DOIs	https://doi.org/10.1002/cctc.201801605
Publication status	Published - Jan 2019

Keywords

Cobalt
hydrosilylation
amides
homogeneous catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/cctc.201801605

https://onlinelibrary.wiley.com/doi/abs/10.1002/cctc.201801605?af=R

1 Visiting an external research institution

Brock University
Khalimon, A. (Visiting researcher)
May 27 2018 → Jun 29 2018
Activity: Visiting types › Visiting an external research institution

Cite this

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abstract = "The readily synthesized and bench‐stable cobalt dichloride complex (dpephos)CoCl2 is employed as a pre‐catalyst for a diversity of silane additions to unsaturated organic molecules, including the normally challenging reduction of amides to amines. With regard to hydrosilative reduction of amides even more effective and activator free catalytic systems can be generated from the bench‐stable, commercially available Co(acac)2 and Co(OAc)2 with dpephos and PPh3 ligands. These systems operate under mild conditions (<100 °C), with many examples of room temperature transformations, presenting a first example of mild cobalt‐catalyzed hydrosilylation of amides",

keywords = "Cobalt, hydrosilylation, amides, homogeneous catalysis",

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AU - Kassymbek, Aishabibi

AU - Segizbayev, Medet

AU - Seilkhanov, Tulegen

AU - Khalimon, Andrey

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KW - Cobalt

KW - hydrosilylation

KW - amides

KW - homogeneous catalysis

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Bench-Stable Cobalt Pre-Catalysts for Mild Hydrosilative Reduction of Tertiary Amides to Amines and Beyond

Abstract

Keywords

UN SDGs

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Brock University

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