GAMMOPATIE MONOCLONALI BENIGNE: PROBABILE SPECIFICITA ANTICORPALE DELLE IMMUNOGLOBULINE MONOCLONALI

Translated title of the contribution: Benign monoclonal gammopathies: Probable antibody specificity of monoclonal immunoglobulins

S. Vento, V. Salpietro, L. Giordano, M. Ugliola, G. M. Costa, P. Cavaciocchi, E. Russomanno

Research output: Contribution to journalArticle

Abstract

40 patients with benign paraproteinemia have been studied in relation to their age and associated diseases. Significantly high frequence of liver disease (CALD, cirrhosis, hepatoma, metastases) has been found (12 over 40 people) and increased incidence of idiopathic paraproteinaemia in the old age has been confirmed. 9 patients have been followed for 5 years, so that one could be sure that they had really benign paraproteinaemia: these patients have been then studied from an immunological point of view, in vivo by means of skin tests (PPD, Candida, Tricophyton, DNCB) and in vitro by searching for circulating immune complexes (using a new highly specific immunoenzymatic method), and compared to controls without paraproteinaemia. Highly positive skin tests have been found only in 7 over 9 patients (even in old subjects) and 6 of them had circulating immune complexes (C.I.C.) in their sera; all the controls were negative both for skin tests and for C.I.C. Immune complexes have been found also in some cases of idiopathic paraproteinaemia, so that they do not seem to be in relation to the associated diseases. The Authors suggest that a genetically determined defect in regulator/suppressor T lymphocyte activity may cause the growth of a benign B cell neoplasm; and the monoclonal immunoglobulins most probably have antibody specificity and are directed against target antigens.

Translated title of the contributionBenign monoclonal gammopathies: Probable antibody specificity of monoclonal immunoglobulins
Original languageItalian
Pages (from-to)2439-2445
Number of pages7
JournalMinerva Medica
Volume74
Issue number41
Publication statusPublished - Dec 1 1983

ASJC Scopus subject areas

  • Medicine(all)

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    Vento, S., Salpietro, V., Giordano, L., Ugliola, M., Costa, G. M., Cavaciocchi, P., & Russomanno, E. (1983). GAMMOPATIE MONOCLONALI BENIGNE: PROBABILE SPECIFICITA ANTICORPALE DELLE IMMUNOGLOBULINE MONOCLONALI. Minerva Medica, 74(41), 2439-2445.