Abstract
Experiments on white noninbred rats were made to study the binding by isolated organoids and distribution in liver cells of etazole, norsulfazole, sulfamonomethoxine and sulfalene. The latter drug was found to be absorbed by organoids to the greatest degree. Drug complexes with organoids were discovered to be capable of dissociating with a partial release of unbound drug. Intracellular distribution of sulfanilamides is marked by their accumulation primarily by the nuclei and to a lesser degree by the mitochondria and microsomes.
| Original language | English |
|---|---|
| Pages (from-to) | 71-74 |
| Number of pages | 4 |
| Journal | Farmakologiya i Toksikologiya |
| Volume | 47 |
| Issue number | 6 |
| Publication status | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Binding and distribution of sulfanilamides in rat liver cells. / Kivman Ya., G.; Gulyaev, A. E.; Sariev, A. K.
In: Farmakologiya i Toksikologiya, Vol. 47, No. 6, 1984, p. 71-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Binding and distribution of sulfanilamides in rat liver cells
AU - Kivman Ya., G.
AU - Gulyaev, A. E.
AU - Sariev, A. K.
PY - 1984
Y1 - 1984
N2 - Experiments on white noninbred rats were made to study the binding by isolated organoids and distribution in liver cells of etazole, norsulfazole, sulfamonomethoxine and sulfalene. The latter drug was found to be absorbed by organoids to the greatest degree. Drug complexes with organoids were discovered to be capable of dissociating with a partial release of unbound drug. Intracellular distribution of sulfanilamides is marked by their accumulation primarily by the nuclei and to a lesser degree by the mitochondria and microsomes.
AB - Experiments on white noninbred rats were made to study the binding by isolated organoids and distribution in liver cells of etazole, norsulfazole, sulfamonomethoxine and sulfalene. The latter drug was found to be absorbed by organoids to the greatest degree. Drug complexes with organoids were discovered to be capable of dissociating with a partial release of unbound drug. Intracellular distribution of sulfanilamides is marked by their accumulation primarily by the nuclei and to a lesser degree by the mitochondria and microsomes.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021134554&partnerID=8YFLogxK
M3 - Article
VL - 47
SP - 71
EP - 74
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 6
ER -