Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease

G. Kivman Ya., A. E. Gulyaev, V. A. Kulishov

Research output: Contribution to journalArticle

Abstract

In vitro binding of tetracycline, gentamicin, erythromycin and rifampicin by the liver organoids and intracellular distribution of the antibiotics in the hepatocytes of rats with acute irradiation disease were studied. Total γ-irradiation of the animals with 60Co in a dose of 750 R resulted in the development of a typical radiation disease and induced pronounced changes in binding of tetracycline, gentamicin and erythromycin by isolated subcellular fractions. Simultaneous impairment of the antibiotic intracellular distribution was observed. Rifampicin interaction with the cell structures was unchanged. It is suggested that there is a relation between the level of the impairment of the antibiotic cell pharmacokinetics in acute radiation disease and the mechanism of the drug intracellular binding in health.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalAntibiotiki i Medicinskaya Biotechnologiya
Volume30
Issue number6
Publication statusPublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease'. Together they form a unique fingerprint.

  • Cite this