In vitro binding of tetracycline, gentamicin, erythromycin and rifampicin by the liver organoids and intracellular distribution of the antibiotics in the hepatocytes of rats with acute irradiation disease were studied. Total γ-irradiation of the animals with 60Co in a dose of 750 R resulted in the development of a typical radiation disease and induced pronounced changes in binding of tetracycline, gentamicin and erythromycin by isolated subcellular fractions. Simultaneous impairment of the antibiotic intracellular distribution was observed. Rifampicin interaction with the cell structures was unchanged. It is suggested that there is a relation between the level of the impairment of the antibiotic cell pharmacokinetics in acute radiation disease and the mechanism of the drug intracellular binding in health.
|Number of pages||4|
|Journal||Antibiotiki i Medicinskaya Biotechnologiya|
|Publication status||Published - Jan 1 1985|
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