Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease

G. Kivman Ya., A. E. Gulyaev, V. A. Kulishov

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In vitro binding of tetracycline, gentamicin, erythromycin and rifampicin by the liver organoids and intracellular distribution of the antibiotics in the hepatocytes of rats with acute irradiation disease were studied. Total γ-irradiation of the animals with 60Co in a dose of 750 R resulted in the development of a typical radiation disease and induced pronounced changes in binding of tetracycline, gentamicin and erythromycin by isolated subcellular fractions. Simultaneous impairment of the antibiotic intracellular distribution was observed. Rifampicin interaction with the cell structures was unchanged. It is suggested that there is a relation between the level of the impairment of the antibiotic cell pharmacokinetics in acute radiation disease and the mechanism of the drug intracellular binding in health.

Original languageEnglish
Title of host publicationAntibiotiki i Medicinskaya Biotechnologiya
Pages438-441
Number of pages4
Volume30
Edition6
Publication statusPublished - 1985
Externally publishedYes

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Subcellular Fractions
Acute Disease
Erythromycin
Radiation
Rifampin
Anti-Bacterial Agents
Gentamicins
Tetracycline
Liver
Organoids
Cell Communication
Hepatocytes
Pharmacokinetics
Health
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kivman Ya., G., Gulyaev, A. E., & Kulishov, V. A. (1985). Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease. In Antibiotiki i Medicinskaya Biotechnologiya (6 ed., Vol. 30, pp. 438-441)

Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease. / Kivman Ya., G.; Gulyaev, A. E.; Kulishov, V. A.

Antibiotiki i Medicinskaya Biotechnologiya. Vol. 30 6. ed. 1985. p. 438-441.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kivman Ya., G, Gulyaev, AE & Kulishov, VA 1985, Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease. in Antibiotiki i Medicinskaya Biotechnologiya. 6 edn, vol. 30, pp. 438-441.
Kivman Ya. G, Gulyaev AE, Kulishov VA. Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease. In Antibiotiki i Medicinskaya Biotechnologiya. 6 ed. Vol. 30. 1985. p. 438-441
Kivman Ya., G. ; Gulyaev, A. E. ; Kulishov, V. A. / Binding of certain antibiotics by subcellular fractions of rat liver homogenates and their intracellular distribution in acute radiation disease. Antibiotiki i Medicinskaya Biotechnologiya. Vol. 30 6. ed. 1985. pp. 438-441
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