Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization role of the cross-linking agent

Paloma Perez, Fatima Plieva, Alberto Gallardo, Julio San Roman, Maria Rosa Aguilar, Isabelle Morfin, Françoise Ehrburger-Dolle, Francoise Bley, Sergey Mikhalovsky, Igor Yu Galaev, Bo Mattiasson

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Macroporous poly(N-isopropylacrylamide) (pNIPA) gels (so-called cryogels), cross-linked with different bisacrylic compounds,N,N'-methylenebisacrylamide (MBAAm) and dimethacrylate-tyrosine-lysine-tyrosine (DMTLT), were prepared through free-radical polymerization at subzero temperature in dioxane/water media. DMTLT is a hydrolytically degradable cross-linker with relatively hydrophobic character. The effects of different synthesis conditions, namely the concentration of monomers, the cross-linker, and the initiator in the reaction mixture, on the structure of the pNIPA-cryogels have been studied. The equilibrium swelling ratio of the DMTLT cross-linked pNIPA cryogels at temperatures below lower critical solution temperature (LCST) of pNIPA, was over ten times higher than that of the gels synthesized at room temperature from the same feed composition. The MBAAm cross-linked pNIPA cryogels synthesized in water exhibited the highest equilibrium swelling and the fastest response. The critical transition temperature, Tc, was lower (Tc ≈ 31 °C) for pNIPA-cryogels synthesized in dioxane/water media or cross-linked with DMTLT as compared to MBAAm cross-linked pNIPA cryogels synthesized in water (Tc ≈ 33 °C). Scanning electron microscopy (SEM) revealed different porous structure and pore surface morphology depending on the cross-linker (MBAAm or DMTLT) and the solvent (water or dioxane/water) used. Gels and cryogels were also characterized by SAXS, showing that the nanostructure of the samples is related to swelling.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalBiomacromolecules
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2008

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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