Blood compatible materials: State of the art

Xiaoli Liu, Lin Yuan, Dan Li, Zengchao Tang, Yanwei Wang, Gaojian Chen, Hong Chen, John L. Brash

Research output: Contribution to journalArticlepeer-review

147 Citations (Scopus)

Abstract

Devices that function in contact with blood are ubiquitous in clinical medicine and biotechnology. These devices include vascular grafts, coronary stents, heart valves, catheters, hemodialysers, heart-lung bypass systems and many others. Blood contact generally leads to thrombosis (among other adverse outcomes), and no material has yet been developed which remains thrombus-free indefinitely and in all situations: extracorporeally, in the venous circulation and in the arterial circulation. In this article knowledge on blood-material interactions and "thromboresistant" materials is reviewed. Current approaches to the development of thromboresistant materials are discussed including surface passivation; incorporation and/or release of anticoagulants, antiplatelet agents and thrombolytic agents; and mimicry of the vascular endothelium. This journal is

Original languageEnglish
Pages (from-to)5718-5738
Number of pages21
JournalJournal of Materials Chemistry B
Volume2
Issue number35
DOIs
Publication statusPublished - Sep 21 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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