Blood compatible materials: State of the art

Xiaoli Liu, Lin Yuan, Dan Li, Zengchao Tang, Yanwei Wang, Gaojian Chen, Hong Chen, John L. Brash

Research output: Contribution to journalArticlepeer-review

165 Citations (Scopus)


Devices that function in contact with blood are ubiquitous in clinical medicine and biotechnology. These devices include vascular grafts, coronary stents, heart valves, catheters, hemodialysers, heart-lung bypass systems and many others. Blood contact generally leads to thrombosis (among other adverse outcomes), and no material has yet been developed which remains thrombus-free indefinitely and in all situations: extracorporeally, in the venous circulation and in the arterial circulation. In this article knowledge on blood-material interactions and "thromboresistant" materials is reviewed. Current approaches to the development of thromboresistant materials are discussed including surface passivation; incorporation and/or release of anticoagulants, antiplatelet agents and thrombolytic agents; and mimicry of the vascular endothelium. This journal is

Original languageEnglish
Pages (from-to)5718-5738
Number of pages21
JournalJournal of Materials Chemistry B
Issue number35
Publication statusPublished - Sep 21 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)


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