Bone Healing and Hormonal Bioassay in Patients with Long-Bone Fractures and Concomitant Head Injury

Fathy G. Khallaf, Elijah O. Kehinde, Sundus Hussein

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The aim of this study is to investigate healing of fractures in patients with concomitant head injuries and to measure blood hormone levels to elucidate the mechanism of a possible accelerated osteogenesis. Materials and Methods: One hundred and sixty-two patients were included in this study and divided into 3 cohorts: group A with head injuries only (n = 52); group B with head injuries as well as long-bone fractures (n = 50); group C with long-bone fractures only (n = 60). Fracture-healing parameters including time of appearance and thickness of the bridging callus, and blood hormonal assays were measured and compared using Student's t test. Results: The mean time to healing was significantly lower in cohort B (6.9 ± 2.9 weeks) than C (22.4 ± 8.7 weeks; p = 0.001). The mean thickness of the healing callus was significantly higher in cohort B (26.3 ± 9.7 mm) than C (8.1 ± 5.9 mm; p = 0.002). The mean healing rate was also higher in cohort B (4.5 ± 2.3 mm/week) than C (0.38 ± 0.21 mm/week; p = 0.001). Blood hormonal assays in group B showed higher values of parathyroid hormone and growth hormone than in group C. However, adrenaline and noradrenaline values were lower in group B than in group C at all measured time intervals, and correspondingly leptin was lower in all groups (p = 0.001). Corticosteroid values were normal in group B compared to slightly higher values in group C, also at all measured time intervals. Conclusion: In this study, healing of fractures in patients with concomitant head injuries was accelerated, thereby indicating an involvement of a combined neurohormonal mechanism.

Original languageEnglish
Pages (from-to)336-342
Number of pages7
JournalMedical Principles and Practice
Volume25
Issue number4
DOIs
Publication statusPublished - Jun 15 2016
Externally publishedYes

Fingerprint

Bone Fractures
Craniocerebral Trauma
Biological Assay
Fracture Healing
Bone and Bones
Bony Callus
Leptin
Parathyroid Hormone
Osteogenesis
Epinephrine
Growth Hormone
Norepinephrine
Adrenal Cortex Hormones
Reference Values
Hormones
Students

Keywords

  • Brain injury
  • Fracture healing
  • Hormonal bioassay
  • Long-bone fractures

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bone Healing and Hormonal Bioassay in Patients with Long-Bone Fractures and Concomitant Head Injury. / Khallaf, Fathy G.; Kehinde, Elijah O.; Hussein, Sundus.

In: Medical Principles and Practice, Vol. 25, No. 4, 15.06.2016, p. 336-342.

Research output: Contribution to journalArticle

Khallaf, Fathy G. ; Kehinde, Elijah O. ; Hussein, Sundus. / Bone Healing and Hormonal Bioassay in Patients with Long-Bone Fractures and Concomitant Head Injury. In: Medical Principles and Practice. 2016 ; Vol. 25, No. 4. pp. 336-342.
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