Brillouin light scattering spectroscopy for tissue engineering application

Dana Akilbekova, Talgat Yakupov, Vyacheslav Ogay, Bauyrzhan Umbayev, Vladislav V. Yakovlev, Zhandos N. Utegulov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biomechanical properties of mammalian bones, such as strength, toughness and plasticity, are essential for understanding how microscopic scale mechanical features can link to macroscale bones' strength and fracture resistance. We employ Brillouin light scattering (BLS) micro-spectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins (BMPs) and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free imaging modality for probing mechanical properties of hard tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that HCF gels containing combination of all factors had the best effect with complete defect regeneration at week 9 and that the bones with fully consolidated fractures have higher values of elastic moduli compared to the bones with defects.

LanguageEnglish
Title of host publicationOptical Elastography and Tissue Biomechanics V
PublisherSPIE
Volume10496
ISBN (Electronic)9781510614772
DOIs
StatePublished - Jan 1 2018
EventOptical Elastography and Tissue Biomechanics V 2018 - San Francisco, United States
Duration: Jan 27 2018Jan 28 2018

Conference

ConferenceOptical Elastography and Tissue Biomechanics V 2018
CountryUnited States
CitySan Francisco
Period1/27/181/28/18

Fingerprint

Brillouin scattering
tissue engineering
Tissue Engineering
Tissue engineering
Light scattering
bones
Spectrum Analysis
Bone
light scattering
Spectroscopy
Light
Bone and Bones
spectroscopy
fibrin
heparins
Fibrin
Tissue
Heparin
Regeneration
regeneration

Keywords

  • biomechanical properties
  • bone morphogenic proteins
  • bones
  • Brillouin light scattering
  • critical sized defect
  • heparin-conjugated fibrin gel
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Akilbekova, D., Yakupov, T., Ogay, V., Umbayev, B., Yakovlev, V. V., & Utegulov, Z. N. (2018). Brillouin light scattering spectroscopy for tissue engineering application. In Optical Elastography and Tissue Biomechanics V (Vol. 10496). [104961I] SPIE. DOI: 10.1117/12.2289923

Brillouin light scattering spectroscopy for tissue engineering application. / Akilbekova, Dana; Yakupov, Talgat; Ogay, Vyacheslav; Umbayev, Bauyrzhan; Yakovlev, Vladislav V.; Utegulov, Zhandos N.

Optical Elastography and Tissue Biomechanics V. Vol. 10496 SPIE, 2018. 104961I.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Akilbekova, D, Yakupov, T, Ogay, V, Umbayev, B, Yakovlev, VV & Utegulov, ZN 2018, Brillouin light scattering spectroscopy for tissue engineering application. in Optical Elastography and Tissue Biomechanics V. vol. 10496, 104961I, SPIE, Optical Elastography and Tissue Biomechanics V 2018, San Francisco, United States, 1/27/18. DOI: 10.1117/12.2289923
Akilbekova D, Yakupov T, Ogay V, Umbayev B, Yakovlev VV, Utegulov ZN. Brillouin light scattering spectroscopy for tissue engineering application. In Optical Elastography and Tissue Biomechanics V. Vol. 10496. SPIE. 2018. 104961I. Available from, DOI: 10.1117/12.2289923
Akilbekova, Dana ; Yakupov, Talgat ; Ogay, Vyacheslav ; Umbayev, Bauyrzhan ; Yakovlev, Vladislav V. ; Utegulov, Zhandos N./ Brillouin light scattering spectroscopy for tissue engineering application. Optical Elastography and Tissue Biomechanics V. Vol. 10496 SPIE, 2018.
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