Brillouin light scattering spectroscopy for tissue engineering application

Dana Akilbekova, Talgat Yakupov, Vyacheslav Ogay, Bauyrzhan Umbayev, Vladislav V. Yakovlev, Zhandos N. Utegulov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Biomechanical properties of mammalian bones, such as strength, toughness and plasticity, are essential for understanding how microscopic scale mechanical features can link to macroscale bones' strength and fracture resistance. We employ Brillouin light scattering (BLS) micro-spectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins (BMPs) and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free imaging modality for probing mechanical properties of hard tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that HCF gels containing combination of all factors had the best effect with complete defect regeneration at week 9 and that the bones with fully consolidated fractures have higher values of elastic moduli compared to the bones with defects.

Original languageEnglish
Title of host publicationOptical Elastography and Tissue Biomechanics V
EditorsDavid D. Sampson, Kirill V. Larin
ISBN (Electronic)9781510614772
Publication statusPublished - Jan 1 2018
EventOptical Elastography and Tissue Biomechanics V 2018 - San Francisco, United States
Duration: Jan 27 2018Jan 28 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Elastography and Tissue Biomechanics V 2018
Country/TerritoryUnited States
CitySan Francisco


  • biomechanical properties
  • bone morphogenic proteins
  • bones
  • Brillouin light scattering
  • critical sized defect
  • heparin-conjugated fibrin gel
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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