Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones

Dana Akilbekova, Vyacheslav Ogay, Talgat Yakupov, Madina Sarsenova, Bauyrzhan Umbayev, Asset Nurakhmetov, Kairat Tazhin, Vladislav V Yakovlev, Zhandos N Utegulov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Biomechanical properties of mammalian bones, such as strength, toughness, and plasticity, are essential for understanding how microscopic-scale mechanical features can link to macroscale bones' strength and fracture resistance. We employ Brillouin light scattering (BLS) microspectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins, and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free modality for probing viscoelastic properties of tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that MCS and BPMs are critically important for regeneration of elastic and viscous properties, respectively, HCF gels containing combination of all factors had the best effect with complete defect regeneration at week nine after the implantation of bone grafts and that the bones with fully consolidated fractures have higher values of elastic moduli compared with defective bones.

Original languageEnglish
Article number097004
Pages (from-to)1-11
Number of pages11
JournalJournal of Biomedical Optics
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 27 2018

Fingerprint

Radiography
radiography
bones
Bone
Spectroscopy
spectroscopy
regeneration
fibrin
heparins
Brillouin scattering
Tissue
Fibrin
Light scattering
Heparin
light scattering
elastic properties
Hydrogels
stem cells
tissue engineering
toughness

Keywords

  • biomechanical properties
  • bone morphogenic proteins
  • bones
  • Brillouin light scattering
  • critical-sized defect
  • elastic
  • heparin-conjugated fibrin gel
  • mesenchymal stem cells
  • viscous

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones. / Akilbekova, Dana; Ogay, Vyacheslav; Yakupov, Talgat; Sarsenova, Madina; Umbayev, Bauyrzhan; Nurakhmetov, Asset; Tazhin, Kairat; Yakovlev, Vladislav V; Utegulov, Zhandos N.

In: Journal of Biomedical Optics, Vol. 23, No. 9, 097004, 27.09.2018, p. 1-11.

Research output: Contribution to journalArticle

Akilbekova, Dana ; Ogay, Vyacheslav ; Yakupov, Talgat ; Sarsenova, Madina ; Umbayev, Bauyrzhan ; Nurakhmetov, Asset ; Tazhin, Kairat ; Yakovlev, Vladislav V ; Utegulov, Zhandos N. / Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones. In: Journal of Biomedical Optics. 2018 ; Vol. 23, No. 9. pp. 1-11.
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