Calcium-binding allergens

From plants to man

Rudoif Valenta, Brigitte Hayek, Susanne Seiberler, Agnes Bugajska-Schretter, Verena Niederberger, Anna Twardosz, Susanne Natter, Luca Vangelista, Annalisa Pastore, Susanne Spirzauer, Dietrich Kraft

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Calcium-binding proteins contain a variable number of motifs, termed EF-hands, which consist of two perpendicularly placed α-helices and an inter-helical loop forming a single calcium-binding site. Due to their ability to bind and transport calcium as well as to interact with a variety of ligands in a calcium-dependent manner, they fulfill important biological functions in eukaryotic cells. After parvalbumin, a three EF-hand fish allergen, calcium-binding allergens were discovered in pollens of trees, grasses and weeds and, recently, as autoallergens in man. Although only a small percentage of atopic individuals displays IgE reactivity to calcium-binding allergens, these allergens may be important because of their ability to cross-sensitize allergic individuals. Conformation and stability as well as IgE recognition of calcium-binding allergens greatly depend on the presence of protein-bound calcium ions. It is thus likely that hypoallergenic derivatives of calcium-binding allergens can be engineered by recombinant DNA technology for immunotherapy of sensitized patients.

Original languageEnglish
Pages (from-to)160-166
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume117
Issue number3
Publication statusPublished - Nov 1998
Externally publishedYes

Fingerprint

Allergens
Calcium
EF Hand Motifs
Immunoglobulin E
Parvalbumins
Calcium-Binding Proteins
Recombinant DNA
Eukaryotic Cells
Pollen
Poaceae
Immunotherapy
Fishes
Binding Sites
Ions
Ligands
Technology
Proteins

Keywords

  • Calcium-binding allergens
  • Cross-reactivity
  • Diagnosis
  • EF-hand motif
  • IgE epitopes
  • Immunotherapy
  • Type I allergy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Valenta, R., Hayek, B., Seiberler, S., Bugajska-Schretter, A., Niederberger, V., Twardosz, A., ... Kraft, D. (1998). Calcium-binding allergens: From plants to man. International Archives of Allergy and Immunology, 117(3), 160-166.

Calcium-binding allergens : From plants to man. / Valenta, Rudoif; Hayek, Brigitte; Seiberler, Susanne; Bugajska-Schretter, Agnes; Niederberger, Verena; Twardosz, Anna; Natter, Susanne; Vangelista, Luca; Pastore, Annalisa; Spirzauer, Susanne; Kraft, Dietrich.

In: International Archives of Allergy and Immunology, Vol. 117, No. 3, 11.1998, p. 160-166.

Research output: Contribution to journalArticle

Valenta, R, Hayek, B, Seiberler, S, Bugajska-Schretter, A, Niederberger, V, Twardosz, A, Natter, S, Vangelista, L, Pastore, A, Spirzauer, S & Kraft, D 1998, 'Calcium-binding allergens: From plants to man', International Archives of Allergy and Immunology, vol. 117, no. 3, pp. 160-166.
Valenta R, Hayek B, Seiberler S, Bugajska-Schretter A, Niederberger V, Twardosz A et al. Calcium-binding allergens: From plants to man. International Archives of Allergy and Immunology. 1998 Nov;117(3):160-166.
Valenta, Rudoif ; Hayek, Brigitte ; Seiberler, Susanne ; Bugajska-Schretter, Agnes ; Niederberger, Verena ; Twardosz, Anna ; Natter, Susanne ; Vangelista, Luca ; Pastore, Annalisa ; Spirzauer, Susanne ; Kraft, Dietrich. / Calcium-binding allergens : From plants to man. In: International Archives of Allergy and Immunology. 1998 ; Vol. 117, No. 3. pp. 160-166.
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