Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes

Petr Dmitriev, Ulykbek Kairov, Thomas Robert, Ana Barat, Vladimir Lazar, Gilles Carnac, Dalila Laoudj-Chenivesse, Yegor S. Vassetzky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.

Original languageEnglish
Pages (from-to)208-217
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Myoblasts
Neoplasm Genes
Skeletal Muscle Fibers
Neoplasms
Transcriptome
Myotonic Dystrophy
Ewing's Sarcoma
Muscular Dystrophies
Genes

Keywords

  • Cancer
  • Ewing's sarcoma
  • FSHD
  • Muscular dystrophy
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Cite this

Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes. / Dmitriev, Petr; Kairov, Ulykbek; Robert, Thomas; Barat, Ana; Lazar, Vladimir; Carnac, Gilles; Laoudj-Chenivesse, Dalila; Vassetzky, Yegor S.

In: Journal of Cellular and Molecular Medicine, Vol. 18, No. 2, 02.2014, p. 208-217.

Research output: Contribution to journalArticle

Dmitriev, P, Kairov, U, Robert, T, Barat, A, Lazar, V, Carnac, G, Laoudj-Chenivesse, D & Vassetzky, YS 2014, 'Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes', Journal of Cellular and Molecular Medicine, vol. 18, no. 2, pp. 208-217. https://doi.org/10.1111/jcmm.12182
Dmitriev, Petr ; Kairov, Ulykbek ; Robert, Thomas ; Barat, Ana ; Lazar, Vladimir ; Carnac, Gilles ; Laoudj-Chenivesse, Dalila ; Vassetzky, Yegor S. / Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes. In: Journal of Cellular and Molecular Medicine. 2014 ; Vol. 18, No. 2. pp. 208-217.
@article{e857baaf64cf484191aeec0e5572af96,
title = "Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes",
abstract = "Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.",
keywords = "Cancer, Ewing's sarcoma, FSHD, Muscular dystrophy, Rhabdomyosarcoma",
author = "Petr Dmitriev and Ulykbek Kairov and Thomas Robert and Ana Barat and Vladimir Lazar and Gilles Carnac and Dalila Laoudj-Chenivesse and Vassetzky, {Yegor S.}",
year = "2014",
month = "2",
doi = "10.1111/jcmm.12182",
language = "English",
volume = "18",
pages = "208--217",
journal = "Journal of Cellular and Molecular Medicine",
issn = "1582-1838",
publisher = "Wiley Blackwell",
number = "2",

}

TY - JOUR

T1 - Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes

AU - Dmitriev, Petr

AU - Kairov, Ulykbek

AU - Robert, Thomas

AU - Barat, Ana

AU - Lazar, Vladimir

AU - Carnac, Gilles

AU - Laoudj-Chenivesse, Dalila

AU - Vassetzky, Yegor S.

PY - 2014/2

Y1 - 2014/2

N2 - Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.

AB - Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.

KW - Cancer

KW - Ewing's sarcoma

KW - FSHD

KW - Muscular dystrophy

KW - Rhabdomyosarcoma

UR - http://www.scopus.com/inward/record.url?scp=84893649447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893649447&partnerID=8YFLogxK

U2 - 10.1111/jcmm.12182

DO - 10.1111/jcmm.12182

M3 - Article

VL - 18

SP - 208

EP - 217

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

SN - 1582-1838

IS - 2

ER -