Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes

Petr Dmitriev, Ulykbek Kairov, Thomas Robert, Ana Barat, Vladimir Lazar, Gilles Carnac, Dalila Laoudj-Chenivesse, Yegor S. Vassetzky

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.

Original languageEnglish
Pages (from-to)208-217
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Cancer
  • Ewing's sarcoma
  • FSHD
  • Muscular dystrophy
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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  • Cite this

    Dmitriev, P., Kairov, U., Robert, T., Barat, A., Lazar, V., Carnac, G., Laoudj-Chenivesse, D., & Vassetzky, Y. S. (2014). Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes. Journal of Cellular and Molecular Medicine, 18(2), 208-217. https://doi.org/10.1111/jcmm.12182