Abstract
One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.
| Original language | English |
|---|---|
| Pages (from-to) | 1010428317692227 |
| Journal | Tumor Biology |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2017 |
| Externally published | Yes |
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Keywords
- Animals
- Autophagy
- Brain Neoplasms
- Cathepsins
- Glioblastoma
- Humans
- Neoplastic Stem Cells
- Proteolysis
- Journal Article
- Review
Cite this
Cancer stem cells : The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells. / Bischof, Joachim; Westhoff, Mike-Andrew; Wagner, Johanna Elisabeth; Halatsch, Marc-Eric; Trentmann, Stephanie; Knippschild, Uwe; Wirtz, Christian Rainer; Burster, Timo.
In: Tumor Biology, Vol. 39, No. 3, 03.2017, p. 1010428317692227.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cancer stem cells
T2 - The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells
AU - Bischof, Joachim
AU - Westhoff, Mike-Andrew
AU - Wagner, Johanna Elisabeth
AU - Halatsch, Marc-Eric
AU - Trentmann, Stephanie
AU - Knippschild, Uwe
AU - Wirtz, Christian Rainer
AU - Burster, Timo
PY - 2017/3
Y1 - 2017/3
N2 - One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.
AB - One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.
KW - Animals
KW - Autophagy
KW - Brain Neoplasms
KW - Cathepsins
KW - Glioblastoma
KW - Humans
KW - Neoplastic Stem Cells
KW - Proteolysis
KW - Journal Article
KW - Review
U2 - 10.1177/1010428317692227
DO - 10.1177/1010428317692227
M3 - Review article
C2 - 28347245
VL - 39
SP - 1010428317692227
JO - Tumor Biology
JF - Tumor Biology
SN - 1010-4283
IS - 3
ER -