Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

Joachim Bischof; Mike-Andrew Westhoff; Johanna Elisabeth Wagner; Marc-Eric Halatsch; Stephanie Trentmann; Uwe Knippschild; Christian Rainer Wirtz; Timo Burster

doi:10.1177/1010428317692227

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

Joachim Bischof, Mike-Andrew Westhoff, Johanna Elisabeth Wagner, Marc-Eric Halatsch, Stephanie Trentmann, Uwe Knippschild, Christian Rainer Wirtz, Timo Burster

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.

Original language	English
Pages (from-to)	1010428317692227
Journal	Tumor Biology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1177/1010428317692227
Publication status	Published - Mar 2017
Externally published	Yes

Keywords

Animals
Autophagy
Brain Neoplasms
Cathepsins
Glioblastoma
Humans
Neoplastic Stem Cells
Proteolysis
Journal Article
Review

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10.1177/1010428317692227

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Cancer stem cells : The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells. / Bischof, Joachim; Westhoff, Mike-Andrew; Wagner, Johanna Elisabeth; Halatsch, Marc-Eric; Trentmann, Stephanie; Knippschild, Uwe; Wirtz, Christian Rainer; Burster, Timo.

In: Tumor Biology, Vol. 39, No. 3, 03.2017, p. 1010428317692227.

Research output: Contribution to journal › Review article › peer-review

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abstract = "One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.",

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T2 - The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

AU - Bischof, Joachim

AU - Westhoff, Mike-Andrew

AU - Wagner, Johanna Elisabeth

AU - Halatsch, Marc-Eric

AU - Trentmann, Stephanie

AU - Knippschild, Uwe

AU - Wirtz, Christian Rainer

AU - Burster, Timo

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AB - One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.

KW - Animals

KW - Autophagy

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Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

Abstract

Keywords

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