CandiVF - Candida albicans virulence factor database

Songsak Tongchusak, Sansanee C. Chaiyaroj, Anitha Veeramani, Judice L.Y. Koh, Vladimir Brusic

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Candida albicans is a pathogen commonly infecting patients who receive immunosuppressive drug therapy, long-term catheterization, or those who suffer from acquired immune deficiency syndrome (AIDS). The major factor accountable for pathogenicity of C. albicans is host immune status. Various virulence molecules, or factors, of are also responsible for the disease progression. Virulence proteins are published in public databases but they normally lack detailed functional annotations. We have developed CandiVF, a specialized database of C. albicans virulence factors (http://antigen.i2r.a-star.edu.sg/ Templar/DB/CandiVF/) to facilitate efficient extraction and analysis of data aimed to assist research on immune responses, pathogenesis, prevention, and control of candidiasis. CandiVF contains a large number of annotated virulence proteins, including secretory, cell wall-associated, membrane, cytoplasmic, and nuclear proteins. This database has in-built bioinformatics tools including keyword and BLAST search, visualization of 3D-structures, HLA-DR epitope prediction, virulence descriptors, and virulence factors ontology.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalInternational Journal of Peptide Research and Therapeutics
Volume11
Issue number4
DOIs
Publication statusPublished - Dec 1 2005

Keywords

  • Candidiasis
  • Fungal diseases
  • Immunoinformatics
  • T-cell epitopes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Bioengineering
  • Biochemistry
  • Molecular Medicine
  • Drug Discovery

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