Carbon dots-mediated fluorescent scaffolds: Recent trends in image-guided tissue engineering applications: Recent trends in image-guided tissue engineering applications

Mohan Vedhanayagam; Iruthayapandi Selestin Raja; Anara Molkenova; Timur Sh Atabaev; Kalarical Janardhanan Sreeram; Dong Wook Han

doi:10.3390/ijms22105378

Carbon dots-mediated fluorescent scaffolds: Recent trends in image-guided tissue engineering applications: Recent trends in image-guided tissue engineering applications

Mohan Vedhanayagam, Iruthayapandi Selestin Raja, Anara Molkenova, Timur Sh Atabaev, Kalarical Janardhanan Sreeram, Dong Wook Han

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

Abstract

Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability. In this review, we provide an overview of the recent advancement of CDs in terms of their different synthesis methods, tunable physicochemical, mechanical, and optical properties, and their application in tissue engineering. Finally, this review concludes the further research directions that can be explored to apply CDs in tissue engineering.

Original language	English
Article number	5378
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	10
DOIs	https://doi.org/10.3390/ijms22105378
Publication status	Published - May 20 2021

Funding

Funding: M.V. would like to thank Council of Scientific and Industrial Research (CSIR), Government of India for the financial support (CSIR RA fellowship Ref. No: 31/006 (0475)/2020-EMR-I). Further, this work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (the Ministry of Science and ICT) (No. 2019R1A4A1024116 and 2021R1A2C2006013) and by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (NTIS Number: 9991006781).

Keywords

Biodegradation
Carbon dots
Fluorescent scaffold
Image-guided tissue engineering
Mechanical strength

ASJC Scopus subject areas

Inorganic Chemistry
Molecular Biology
Spectroscopy
Physical and Theoretical Chemistry

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10.3390/ijms22105378

Cite this

Vedhanayagam, M., Raja, I. S., Molkenova, A., Atabaev, T. S., Sreeram, K. J., & Han, D. W. (2021). Carbon dots-mediated fluorescent scaffolds: Recent trends in image-guided tissue engineering applications: Recent trends in image-guided tissue engineering applications. International Journal of Molecular Sciences, 22(10), Article 5378. https://doi.org/10.3390/ijms22105378

Carbon dots-mediated fluorescent scaffolds: Recent trends in image-guided tissue engineering applications: Recent trends in image-guided tissue engineering applications. / Vedhanayagam, Mohan; Raja, Iruthayapandi Selestin; Molkenova, Anara et al.
In: International Journal of Molecular Sciences, Vol. 22, No. 10, 5378, 20.05.2021.

Research output: Contribution to journal › Review article › peer-review

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Carbon dots-mediated fluorescent scaffolds: Recent trends in image-guided tissue engineering applications: Recent trends in image-guided tissue engineering applications

Abstract

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Keywords

ASJC Scopus subject areas

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