Carbon dots-mediated fluorescent scaffolds: Recent trends in image-guided tissue engineering applications: Recent trends in image-guided tissue engineering applications

Mohan Vedhanayagam, Iruthayapandi Selestin Raja, Anara Molkenova, Timur Sh Atabaev, Kalarical Janardhanan Sreeram, Dong Wook Han

Research output: Contribution to journalReview articlepeer-review

Abstract

Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability. In this review, we provide an overview of the recent advancement of CDs in terms of their different synthesis methods, tunable physicochemical, mechanical, and optical properties, and their application in tissue engineering. Finally, this review concludes the further research directions that can be explored to apply CDs in tissue engineering.

Original languageEnglish
Article number5378
JournalInternational Journal of Molecular Sciences
Volume22
Issue number10
DOIs
Publication statusPublished - May 20 2021

Keywords

  • Biodegradation
  • Carbon dots
  • Fluorescent scaffold
  • Image-guided tissue engineering
  • Mechanical strength

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Molecular Biology
  • Spectroscopy
  • Physical and Theoretical Chemistry

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