Abstract
Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability. In this review, we provide an overview of the recent advancement of CDs in terms of their different synthesis methods, tunable physicochemical, mechanical, and optical properties, and their application in tissue engineering. Finally, this review concludes the further research directions that can be explored to apply CDs in tissue engineering.
Original language | English |
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Article number | 5378 |
Journal | International Journal of Molecular Sciences |
Volume | 22 |
Issue number | 10 |
DOIs | |
Publication status | Published - May 20 2021 |
Funding
Funding: M.V. would like to thank Council of Scientific and Industrial Research (CSIR), Government of India for the financial support (CSIR RA fellowship Ref. No: 31/006 (0475)/2020-EMR-I). Further, this work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (the Ministry of Science and ICT) (No. 2019R1A4A1024116 and 2021R1A2C2006013) and by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (NTIS Number: 9991006781).
Keywords
- Biodegradation
- Carbon dots
- Fluorescent scaffold
- Image-guided tissue engineering
- Mechanical strength
ASJC Scopus subject areas
- Inorganic Chemistry
- Molecular Biology
- Spectroscopy
- Physical and Theoretical Chemistry