Cathepsin G and its Dichotomous Role in Modulating Levels of MHC Class I Molecules

Timo Burster, Uwe Knippschild, Ferdinand Molnár, Anuar Zhanapiya

Research output: Contribution to journalReview articlepeer-review

Abstract

Cathepsin G (CatG) is involved in controlling numerous processes of the innate and adaptive immune system. These features include the proteolytic activity of CatG and play a pivotal role in alteration of chemokines as well as cytokines, clearance of exogenous and internalized pathogens, platelet activation, apoptosis, and antigen processing. This is in contrast to the capability of CatG acting in a proteolytic-independent manner due to the net charge of arginine residues in the CatG sequence which interferes with bacteria. CatG is a double-edged sword; CatG is also responsible in pathophysiological conditions, such as autoimmunity, chronic pulmonary diseases, HIV infection, tumor progression and metastasis, photo-aged human skin, Papillon–Lefèvre syndrome, and chronic inflammatory pain. Here, we summarize the latest findings for functional responsibilities of CatG in immunity, including bivalent regulation of major histocompatibility complex class I molecules, which underscore an additional novel role of CatG within the immune system.

Original languageEnglish
Article number25
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume68
Issue number4
DOIs
Publication statusPublished - Aug 1 2020

Keywords

  • Cathepsin G
  • Lactoferrin
  • MHC
  • NK cells
  • Protease-activated receptor
  • Proteases
  • T regulatory cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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