We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.
|Number of pages||5|
|Journal||Recenti Progressi in Medicina|
|Publication status||Published - Oct 1 2007|
- Lymphocytes T CD4+
- Structured HAART interruption
ASJC Scopus subject areas