L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV

Translated title of the contribution: CD4+ guided interruption HAART in HIV patients

Dario Antolini, Massimiliano Lanzafame, Emanuela Lattuada, Sandro Vento, Ercole Concia

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.

Original languageItalian
Pages (from-to)501-505
Number of pages5
JournalRecenti Progressi in Medicina
Volume98
Issue number10
Publication statusPublished - Oct 2007
Externally publishedYes

Fingerprint

Highly Active Antiretroviral Therapy
HIV
Opportunistic Infections
Peripheral Nervous System Diseases
Viral Load
Pregnancy
Therapeutics
Acute Retroviral Syndrome
Thrombocytopenia 1

Keywords

  • HAART
  • HIV
  • Lymphocytes T CD4+
  • Structured HAART interruption

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antolini, D., Lanzafame, M., Lattuada, E., Vento, S., & Concia, E. (2007). L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV. Recenti Progressi in Medicina, 98(10), 501-505.

L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV. / Antolini, Dario; Lanzafame, Massimiliano; Lattuada, Emanuela; Vento, Sandro; Concia, Ercole.

In: Recenti Progressi in Medicina, Vol. 98, No. 10, 10.2007, p. 501-505.

Research output: Contribution to journalArticle

Antolini, D, Lanzafame, M, Lattuada, E, Vento, S & Concia, E 2007, 'L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV', Recenti Progressi in Medicina, vol. 98, no. 10, pp. 501-505.
Antolini, Dario ; Lanzafame, Massimiliano ; Lattuada, Emanuela ; Vento, Sandro ; Concia, Ercole. / L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV. In: Recenti Progressi in Medicina. 2007 ; Vol. 98, No. 10. pp. 501-505.
@article{cb85e077cdbd4317b770946a8edec998,
title = "L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV",
abstract = "We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.",
keywords = "HAART, HIV, Lymphocytes T CD4+, Structured HAART interruption",
author = "Dario Antolini and Massimiliano Lanzafame and Emanuela Lattuada and Sandro Vento and Ercole Concia",
year = "2007",
month = "10",
language = "Italian",
volume = "98",
pages = "501--505",
journal = "Recenti Progressi in Medicina",
issn = "0034-1193",
publisher = "Il Pensiero Scientifico Editore s.r.l.",
number = "10",

}

TY - JOUR

T1 - L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV

AU - Antolini, Dario

AU - Lanzafame, Massimiliano

AU - Lattuada, Emanuela

AU - Vento, Sandro

AU - Concia, Ercole

PY - 2007/10

Y1 - 2007/10

N2 - We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.

AB - We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.

KW - HAART

KW - HIV

KW - Lymphocytes T CD4+

KW - Structured HAART interruption

UR - http://www.scopus.com/inward/record.url?scp=36049004433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36049004433&partnerID=8YFLogxK

M3 - Article

VL - 98

SP - 501

EP - 505

JO - Recenti Progressi in Medicina

JF - Recenti Progressi in Medicina

SN - 0034-1193

IS - 10

ER -