L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV

Dario Antolini; Massimiliano Lanzafame; Emanuela Lattuada; Sandro Vento; Ercole Concia

L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV

Translated title of the contribution: CD4+ guided interruption HAART in HIV patients

Dario Antolini, Massimiliano Lanzafame, Emanuela Lattuada, Sandro Vento, Ercole Concia

Department of Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.

Translated title of the contribution	CD4+ guided interruption HAART in HIV patients
Original language	Italian
Pages (from-to)	501-505
Number of pages	5
Journal	Recenti Progressi in Medicina
Volume	98
Issue number	10
Publication status	Published - Oct 1 2007

Keywords

HAART
HIV
Lymphocytes T CD4+
Structured HAART interruption

ASJC Scopus subject areas

Medicine(all)

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title = "L'interruzione CD4+ guidata della terapia antiretrovirale dell'infezione da HIV",

abstract = "We have evaluated CD4+-guided HAART interruption in 46 HIV+ patients with CD4+>500/μl and viral load undetectable since at least 3 years. This strategy resulted effective in a long mean period of treatment interruption (18 months) and safe. In fact during the follow up period we didn't observed any case of death or opportunistic infection. Reintroduction of HAART was caused by: CD4+ fall under 200/μl (6 cases), acute retroviral syndrome (4), individual choice (2), asymptomatic thrombocytopenia (1), peripheral neuropathy (1), pregnancy (1). A low CD4+ nadir level was correlated to a short treatment interruption period.",

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AU - Lattuada, Emanuela

AU - Vento, Sandro

AU - Concia, Ercole

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