Cell encapsulation

Promise and progress

Gorka Orive, Rosa María Hernández, Alicia R. Gascón, Riccardo Calafiore, Thomas M S Chang, Paul De Vos, Gonzalo Hortelano, David Hunkeler, Igor Lacík, A. M James Shapiro, José Luis Pedraz

Research output: Contribution to journalArticle

444 Citations (Scopus)

Abstract

In cell encapsulation, transplanted cells are protected from immune rejection by an artificial, semipermeable membrane, potentially allowing transplantation (allo- or xenotransplantation) without the need for immunosuppression. Yet, despite some promising results in animal studies, the field has not lived up to expectations, and clinical products based on encapsulated cell technology continue to elude the scientific community. This commentary discusses the reasons for this, summarizes recent progress in the field and outlines what is needed to bring this technology closer to clinical application.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalNature Medicine
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2003
Externally publishedYes

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Encapsulation
Technology
Artificial Membranes
Heterologous Transplantation
Animals
Membranes
Immunosuppression
Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Orive, G., Hernández, R. M., Gascón, A. R., Calafiore, R., Chang, T. M. S., De Vos, P., ... Pedraz, J. L. (2003). Cell encapsulation: Promise and progress. Nature Medicine, 9(1), 104-107. https://doi.org/10.1038/nm0103-104

Cell encapsulation : Promise and progress. / Orive, Gorka; Hernández, Rosa María; Gascón, Alicia R.; Calafiore, Riccardo; Chang, Thomas M S; De Vos, Paul; Hortelano, Gonzalo; Hunkeler, David; Lacík, Igor; Shapiro, A. M James; Pedraz, José Luis.

In: Nature Medicine, Vol. 9, No. 1, 01.01.2003, p. 104-107.

Research output: Contribution to journalArticle

Orive, G, Hernández, RM, Gascón, AR, Calafiore, R, Chang, TMS, De Vos, P, Hortelano, G, Hunkeler, D, Lacík, I, Shapiro, AMJ & Pedraz, JL 2003, 'Cell encapsulation: Promise and progress', Nature Medicine, vol. 9, no. 1, pp. 104-107. https://doi.org/10.1038/nm0103-104
Orive G, Hernández RM, Gascón AR, Calafiore R, Chang TMS, De Vos P et al. Cell encapsulation: Promise and progress. Nature Medicine. 2003 Jan 1;9(1):104-107. https://doi.org/10.1038/nm0103-104
Orive, Gorka ; Hernández, Rosa María ; Gascón, Alicia R. ; Calafiore, Riccardo ; Chang, Thomas M S ; De Vos, Paul ; Hortelano, Gonzalo ; Hunkeler, David ; Lacík, Igor ; Shapiro, A. M James ; Pedraz, José Luis. / Cell encapsulation : Promise and progress. In: Nature Medicine. 2003 ; Vol. 9, No. 1. pp. 104-107.
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