CELL-MEDIATED IMMUNITY AND SUPPRESSOR-T-CELL DEFECTS TO LIVER-DERIVED ANTIGENS IN FAMILIES OF PATIENTS WITH AUTOIMMUNE CHRONIC ACTIVE HEPATITIS

C. J. O'Brien, P. T. Donaldson, I. G. Mcfarlane, S. Vento, ClaireG Mcsorley, Roger Williams, A. L W F Eddleston

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

By means of an indirect T-lymphocyte migration inhibitory factor assay, T-cell sensitisation to the asialoglycoprotein receptor, a liver-specific protein on the surface of hepatocytes, was found in patients with autoimmune chronic active hepatitis (CAH) but not in healthy relatives or spouses. Cellular immunity to a liver-derived lipoprotein complex (LSP) which also contains the asialoglycoprotein receptor, and to which immune reactions have been previously demonstrated in patients with CAH, was also examined. In contrast to the findings with the purified asialoglycoprotein receptor, cell-mediated sensitisation to LSP was detected in all the patients and also in 24% of first-degree relatives and 27% of spouses, suggesting an environmental influence. There was a functional defect in suppressor T lymphocytes specific for liver-derived antigens in 50% of first-degree relatives and 43% of second-degree relatives, but in only 9% of spouses. This abnormality of immunoregulation may be genetically determined and crucial to the development of the disease.

Original languageEnglish
Pages (from-to)350-353
Number of pages4
JournalThe Lancet
Volume327
Issue number8477
DOIs
Publication statusPublished - Feb 15 1986
Externally publishedYes

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Autoimmune Hepatitis
Asialoglycoprotein Receptor
Chronic Hepatitis
Cellular Immunity
Spouses
T-Lymphocytes
Antigens
Liver
TCF Transcription Factors
Lipoproteins
Hepatocytes
Membrane Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

CELL-MEDIATED IMMUNITY AND SUPPRESSOR-T-CELL DEFECTS TO LIVER-DERIVED ANTIGENS IN FAMILIES OF PATIENTS WITH AUTOIMMUNE CHRONIC ACTIVE HEPATITIS. / O'Brien, C. J.; Donaldson, P. T.; Mcfarlane, I. G.; Vento, S.; Mcsorley, ClaireG; Williams, Roger; Eddleston, A. L W F.

In: The Lancet, Vol. 327, No. 8477, 15.02.1986, p. 350-353.

Research output: Contribution to journalArticle

O'Brien, C. J. ; Donaldson, P. T. ; Mcfarlane, I. G. ; Vento, S. ; Mcsorley, ClaireG ; Williams, Roger ; Eddleston, A. L W F. / CELL-MEDIATED IMMUNITY AND SUPPRESSOR-T-CELL DEFECTS TO LIVER-DERIVED ANTIGENS IN FAMILIES OF PATIENTS WITH AUTOIMMUNE CHRONIC ACTIVE HEPATITIS. In: The Lancet. 1986 ; Vol. 327, No. 8477. pp. 350-353.
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abstract = "By means of an indirect T-lymphocyte migration inhibitory factor assay, T-cell sensitisation to the asialoglycoprotein receptor, a liver-specific protein on the surface of hepatocytes, was found in patients with autoimmune chronic active hepatitis (CAH) but not in healthy relatives or spouses. Cellular immunity to a liver-derived lipoprotein complex (LSP) which also contains the asialoglycoprotein receptor, and to which immune reactions have been previously demonstrated in patients with CAH, was also examined. In contrast to the findings with the purified asialoglycoprotein receptor, cell-mediated sensitisation to LSP was detected in all the patients and also in 24{\%} of first-degree relatives and 27{\%} of spouses, suggesting an environmental influence. There was a functional defect in suppressor T lymphocytes specific for liver-derived antigens in 50{\%} of first-degree relatives and 43{\%} of second-degree relatives, but in only 9{\%} of spouses. This abnormality of immunoregulation may be genetically determined and crucial to the development of the disease.",
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