Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets

Adriane Penczek, Timo Burster

Research output: Contribution to journalArticle

Abstract

The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of immune cells to provoke the proteolytic processing of cytokines and chemokines in order to stimulate lymphocytes. The present study analyzed peripheral blood mononuclear cells to characterize T cell populations in terms of their CatG content by flow cytometry. It was identified that CatG was exclusively present on the cell surface of a subset of T regulatory cells (Tregs), cluster of differentiation (CD) 39+ Tregs, which expressed CatG in contrast to CD39- Tregs. Additionally, CatG was expressed on double positive CD4+CD8+ T cells, T helper (Th) 9 cells and Th22 cells, implicating CatG as a novel marker to distinguish certain T cell subsets.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalBiomedical Reports
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2019
Externally publishedYes

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Cathepsin G
T-cells
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
T-Lymphocytes
Lymphocytes
Flow cytometry
Immune system
Serine Proteases
Helper-Inducer T-Lymphocytes
Chemokines
Cell Differentiation
Immune System
Blood Cells
Flow Cytometry
Neutrophils
Blood
Cytokines
Processing

Cite this

Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets. / Penczek, Adriane; Burster, Timo.

In: Biomedical Reports, Vol. 10, No. 4, 04.2019, p. 245-249.

Research output: Contribution to journalArticle

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