Centrosome behaviour and orientation of centrioles under the action of energy transfer inhibitors.

I. B. Alieva, I. A. Vorobjev

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

2,4-dinitrophenol, dinitrophenol together with deoxyglucose, sodium azide and ouabain didn't alter cytoplasmic microtubule (MT) network of cultured PK (pig kidney embryo) cells, meanwhile they induced an increase in the average number of pericentriolar satellites and percentage of centrioles with the primary cilium in these cells. Also all drugs studied increase number of MTs attached to and oriented towards the centrosome. Under the action of ouabain the total number of MTs around the centrosome doubled, meanwhile the number of long MTs emanating from the centrosome increased more than 15 times. Under the action of all drugs studied, except sodium azide, the number of maternal centrioles oriented perpendicularly to the substrate surface increased significantly from that in control cells.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalCell Biology International
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1995

Keywords

  • centriole
  • centrosome
  • energy transfer inhibitors
  • microtubules

ASJC Scopus subject areas

  • Cell Biology

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