Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation

Alexander F. Jeans, Ian Frayling, Bharat Jasani, Lucy Side, Claire Blesing, Olaf Ansorge

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. a 37-year-old woman presented with a supratentorial cerebral mass, which was diagnosed histologically as a primitive neuroectodermal tumor. she had been treated for rectal adenocarcinoma 7 years previously. a family history revealed a young-onset colorectal carcinoma in the patient's father. Investigations. Immunohistochemical analysis for dNa mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2. Management. Debulking of the cerebral tumor, craniospinal axis radiotherapy, and genetic counseling of family.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalNature Reviews Clinical Oncology
Volume6
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Primitive Neuroectodermal Tumors
Germ-Line Mutation
Hereditary Nonpolyposis Colorectal Neoplasms
Mutation
DNA Mismatch Repair
Genetic Counseling
Fathers
Colorectal Neoplasms
Adenocarcinoma
Radiotherapy
Neoplasms
Proteins

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

Cite this

Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. / Jeans, Alexander F.; Frayling, Ian; Jasani, Bharat; Side, Lucy; Blesing, Claire; Ansorge, Olaf.

In: Nature Reviews Clinical Oncology, Vol. 6, No. 5, 2009, p. 295-299.

Research output: Contribution to journalArticle

Jeans, AF, Frayling, I, Jasani, B, Side, L, Blesing, C & Ansorge, O 2009, 'Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation', Nature Reviews Clinical Oncology, vol. 6, no. 5, pp. 295-299. https://doi.org/10.1038/nrclinonc.2009.35
Jeans, Alexander F. ; Frayling, Ian ; Jasani, Bharat ; Side, Lucy ; Blesing, Claire ; Ansorge, Olaf. / Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. In: Nature Reviews Clinical Oncology. 2009 ; Vol. 6, No. 5. pp. 295-299.
@article{4f6dc435c49344a3bf32d28b4d9a3889,
title = "Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation",
abstract = "Background. a 37-year-old woman presented with a supratentorial cerebral mass, which was diagnosed histologically as a primitive neuroectodermal tumor. she had been treated for rectal adenocarcinoma 7 years previously. a family history revealed a young-onset colorectal carcinoma in the patient's father. Investigations. Immunohistochemical analysis for dNa mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2. Management. Debulking of the cerebral tumor, craniospinal axis radiotherapy, and genetic counseling of family.",
author = "Jeans, {Alexander F.} and Ian Frayling and Bharat Jasani and Lucy Side and Claire Blesing and Olaf Ansorge",
year = "2009",
doi = "10.1038/nrclinonc.2009.35",
language = "English",
volume = "6",
pages = "295--299",
journal = "Nature Reviews Clinical Oncology",
issn = "1759-4774",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation

AU - Jeans, Alexander F.

AU - Frayling, Ian

AU - Jasani, Bharat

AU - Side, Lucy

AU - Blesing, Claire

AU - Ansorge, Olaf

PY - 2009

Y1 - 2009

N2 - Background. a 37-year-old woman presented with a supratentorial cerebral mass, which was diagnosed histologically as a primitive neuroectodermal tumor. she had been treated for rectal adenocarcinoma 7 years previously. a family history revealed a young-onset colorectal carcinoma in the patient's father. Investigations. Immunohistochemical analysis for dNa mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2. Management. Debulking of the cerebral tumor, craniospinal axis radiotherapy, and genetic counseling of family.

AB - Background. a 37-year-old woman presented with a supratentorial cerebral mass, which was diagnosed histologically as a primitive neuroectodermal tumor. she had been treated for rectal adenocarcinoma 7 years previously. a family history revealed a young-onset colorectal carcinoma in the patient's father. Investigations. Immunohistochemical analysis for dNa mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2. Management. Debulking of the cerebral tumor, craniospinal axis radiotherapy, and genetic counseling of family.

UR - http://www.scopus.com/inward/record.url?scp=67651206070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651206070&partnerID=8YFLogxK

U2 - 10.1038/nrclinonc.2009.35

DO - 10.1038/nrclinonc.2009.35

M3 - Article

C2 - 19390556

AN - SCOPUS:67651206070

VL - 6

SP - 295

EP - 299

JO - Nature Reviews Clinical Oncology

JF - Nature Reviews Clinical Oncology

SN - 1759-4774

IS - 5

ER -