Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation

Alexander F. Jeans, Ian Frayling, Bharat Jasani, Lucy Side, Claire Blesing, Olaf Ansorge

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. a 37-year-old woman presented with a supratentorial cerebral mass, which was diagnosed histologically as a primitive neuroectodermal tumor. she had been treated for rectal adenocarcinoma 7 years previously. a family history revealed a young-onset colorectal carcinoma in the patient's father. Investigations. Immunohistochemical analysis for dNa mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2. Management. Debulking of the cerebral tumor, craniospinal axis radiotherapy, and genetic counseling of family.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalNature Reviews Clinical Oncology
Volume6
Issue number5
DOIs
Publication statusPublished - Oct 26 2009

ASJC Scopus subject areas

  • Oncology

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