Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel

Giuseppe Gagliardi, Olcay Kandemir, Michelle Guida, Serena Benvestito, Gordon W H Stamp, Massimo Pignatelli, Theo G M Ruers, Irving S. Benjamin, John M A Northover, Ian C. Talbot

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

We have used an avidin-biotin immunoperoxidase technique to localise epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, in 107 paraffin-embedded sections from 93 patients consisting of 24 with colorectal adenoma, 55 with rectal carcinoma and 14 with liver metastases. The corresponding primary colorectal tumours were also studied in these cases. E-cadherin was expressed by normal colorectal epithelial cells with typical membranous staining at the intercellular junctions. Loss of normal membranous E-cadherin expression and presence of cytoplasmic staining were found frequently in adenomas larger than 1 cm (P

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalVirchows Archiv
Volume426
Issue number2
DOIs
Publication statusPublished - Mar 1995
Externally publishedYes

Fingerprint

Cadherins
Adenoma
Carcinoma
Staining and Labeling
Intercellular Junctions
Avidin
Cell Adhesion Molecules
Biotin
Immunoenzyme Techniques
Paraffin
Colorectal Neoplasms
Epithelial Cells
Neoplasm Metastasis
Calcium
Liver

Keywords

  • Adenoma
  • Carcinoma
  • Colon
  • E-cadherin
  • Tumour grade

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Gagliardi, G., Kandemir, O., Guida, M., Benvestito, S., Stamp, G. W. H., Pignatelli, M., ... Talbot, I. C. (1995). Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Archiv, 426(2), 149-154. https://doi.org/10.1007/BF00192636

Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. / Gagliardi, Giuseppe; Kandemir, Olcay; Guida, Michelle; Benvestito, Serena; Stamp, Gordon W H; Pignatelli, Massimo; Ruers, Theo G M; Benjamin, Irving S.; Northover, John M A; Talbot, Ian C.

In: Virchows Archiv, Vol. 426, No. 2, 03.1995, p. 149-154.

Research output: Contribution to journalArticle

Gagliardi, G, Kandemir, O, Guida, M, Benvestito, S, Stamp, GWH, Pignatelli, M, Ruers, TGM, Benjamin, IS, Northover, JMA & Talbot, IC 1995, 'Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel', Virchows Archiv, vol. 426, no. 2, pp. 149-154. https://doi.org/10.1007/BF00192636
Gagliardi, Giuseppe ; Kandemir, Olcay ; Guida, Michelle ; Benvestito, Serena ; Stamp, Gordon W H ; Pignatelli, Massimo ; Ruers, Theo G M ; Benjamin, Irving S. ; Northover, John M A ; Talbot, Ian C. / Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. In: Virchows Archiv. 1995 ; Vol. 426, No. 2. pp. 149-154.
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