Characterising nanoporous carbon adsorbents for biological application to chronic kidney disease

Susan Sandeman, Malin Petersson, Sara Wiezell, Carol Howell, Gary Phillips, Yishan Zheng, Steve Tennison, Oleksandr Kozynchenko, Sergey Mikhalovsky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The study characterises a range of advanced MAST carbons derived from pyrolysed porous phenolic resins for use in biological applications, considering how the porosity of the carbons impacts both the methods used to assess potential cytotoxicity and the removal of biological molecules relevant to kidney disease. The large surface area and pore volume available for adsorption make both the microporous and the mesoporous MAST carbons suitable for creatinine removal but not for removal of the small but highly water soluble urea. However, only the highly adsorbent MAST carbons with meso- and macroporosity were able to remove the high molecular weight inflammatory cytokine IL-6. It is the adsorption of the larger biological toxins, represented by IL-6 in this study and not removed by purely microporous carbons or in current haemodialysis therapy, which could most significantly contribute to the augmentation of current haemoperfusion therapy.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalJournal of Biomaterials and Tissue Engineering
Volume2
Issue number1
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Fingerprint

Chronic Renal Insufficiency
Adsorbents
Carbon
Adsorption
Interleukin-6
Biological Toxins
Hemoperfusion
Phenolic resins
Porosity
Kidney Diseases
Cytotoxicity
Urea
Renal Dialysis
Creatinine
Molecular Weight
Molecular weight
Cytokines
Molecules
Water
Therapeutics

Keywords

  • Activated carbon
  • Adsorbent
  • Chronic kidney disease
  • Uraemic toxins

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)

Cite this

Sandeman, S., Petersson, M., Wiezell, S., Howell, C., Phillips, G., Zheng, Y., ... Mikhalovsky, S. (2012). Characterising nanoporous carbon adsorbents for biological application to chronic kidney disease. Journal of Biomaterials and Tissue Engineering, 2(1), 40-47. https://doi.org/10.1166/jbt.2012.1026

Characterising nanoporous carbon adsorbents for biological application to chronic kidney disease. / Sandeman, Susan; Petersson, Malin; Wiezell, Sara; Howell, Carol; Phillips, Gary; Zheng, Yishan; Tennison, Steve; Kozynchenko, Oleksandr; Mikhalovsky, Sergey.

In: Journal of Biomaterials and Tissue Engineering, Vol. 2, No. 1, 03.2012, p. 40-47.

Research output: Contribution to journalArticle

Sandeman, S, Petersson, M, Wiezell, S, Howell, C, Phillips, G, Zheng, Y, Tennison, S, Kozynchenko, O & Mikhalovsky, S 2012, 'Characterising nanoporous carbon adsorbents for biological application to chronic kidney disease', Journal of Biomaterials and Tissue Engineering, vol. 2, no. 1, pp. 40-47. https://doi.org/10.1166/jbt.2012.1026
Sandeman, Susan ; Petersson, Malin ; Wiezell, Sara ; Howell, Carol ; Phillips, Gary ; Zheng, Yishan ; Tennison, Steve ; Kozynchenko, Oleksandr ; Mikhalovsky, Sergey. / Characterising nanoporous carbon adsorbents for biological application to chronic kidney disease. In: Journal of Biomaterials and Tissue Engineering. 2012 ; Vol. 2, No. 1. pp. 40-47.
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