Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant

Alexander K N Lam, Match W L Ko, Leo K K Leung, John C K Kwok, Mathew M F Yuen, David C C Lam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Filling aneurysms with embolization coils is a widely used part of the treatment to stop intracranial aneurysm from rupturing. However, the effect of coiling on aneurysmal pressure has not been established. In this study, the effect of intra-aneurysmal coiling on pressure reduction was characterized. Coil deployment in the aneurysm will disturb flow and may induce aneurysmal coagulation. These effects were experimentally examined in this study using silicone rubber saccular aneurysm models. Changes in aneurysmal blood pressure under pulsatile flow were characterized. With coils in the aneurysm, results showed that flow reduction of anti-coagulated blood in the aneurysm did not reduce aneurysmal pressure. Significant pressure reduction was observed only when the blood's coagulation ability is restored to normal. These results suggest that blood coagulation is pivotal to pressure reduction and concomitant with rupture risk reduction in treatments of aneurysm with coils.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages739-742
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

Fingerprint

Coagulants
Aneurysm
Blood
Pressure
Coagulation
Blood Coagulation
Pulsatile flow
Blood pressure
Pulsatile Flow
Silicone Elastomers
Aptitude
Silicones
Intracranial Aneurysm
Risk Reduction Behavior
Rubber
Rupture
Blood Pressure

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Lam, A. K. N., Ko, M. W. L., Leung, L. K. K., Kwok, J. C. K., Yuen, M. M. F., & Lam, D. C. C. (2013). Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 739-742). [6609606] https://doi.org/10.1109/EMBC.2013.6609606

Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant. / Lam, Alexander K N; Ko, Match W L; Leung, Leo K K; Kwok, John C K; Yuen, Mathew M F; Lam, David C C.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. p. 739-742 6609606.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lam, AKN, Ko, MWL, Leung, LKK, Kwok, JCK, Yuen, MMF & Lam, DCC 2013, Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6609606, pp. 739-742, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13. https://doi.org/10.1109/EMBC.2013.6609606
Lam AKN, Ko MWL, Leung LKK, Kwok JCK, Yuen MMF, Lam DCC. Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. p. 739-742. 6609606 https://doi.org/10.1109/EMBC.2013.6609606
Lam, Alexander K N ; Ko, Match W L ; Leung, Leo K K ; Kwok, John C K ; Yuen, Mathew M F ; Lam, David C C. / Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. pp. 739-742
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