Characterization of sonicated breath films by Atomic Force Microscopy

T. Saliev, M. J. Mullan, Y. Cui, P. A. Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Porous structures offer a vast range of important industrial applications. In the context of medicine, and specifically in the area of controlled drug delivery, spatial [and temporal] control over local porosity has a significant influence on net molecular flux through [membrane-based] controlled release platforms. Such systems may be formulated as oral, transdermal, or even implantable entities, and address chronic infusion needs covering such ailments as diabetes, cancer and hypertension. In all the aforementioned situations, a facility to spatially control porosity could offer significant advantage, such as safer controlled release over extended durations. We have previously described a novel route to engineering-in such flexibility within polymeric thin films by modifying spin-coating protocols to accommodate breath film patterning, that is, the spatially controlled condensation of pore forming droplets onto a liquid-polymer film. Here we demonstrate that those same breath film structures are acoustially responsive. We show, using AFM that the integrity of such films can be compromised to form a leaky structure through which solutions can diffuse. We advocate the use of such films as depot capping structures for controlled drug delivery.

Original languageEnglish
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages2066-2067
Number of pages2
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing, China
Duration: Nov 2 2008Nov 5 2008

Other

Other2008 IEEE International Ultrasonics Symposium, IUS 2008
CountryChina
CityBeijing
Period11/2/0811/5/08

Fingerprint

atomic force microscopy
porosity
delivery
drugs
hypertension
medicine
integrity
coating
flexibility
coverings
platforms
condensation
cancer
routes
engineering
membranes
polymers
liquids
thin films

Keywords

  • Breath figure
  • Polymer
  • Porous
  • Thermal imaging drug delivery

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Saliev, T., Mullan, M. J., Cui, Y., & Campbell, P. A. (2008). Characterization of sonicated breath films by Atomic Force Microscopy. In Proceedings - IEEE Ultrasonics Symposium (pp. 2066-2067). [4803674] https://doi.org/10.1109/ULTSYM.2008.0510

Characterization of sonicated breath films by Atomic Force Microscopy. / Saliev, T.; Mullan, M. J.; Cui, Y.; Campbell, P. A.

Proceedings - IEEE Ultrasonics Symposium. 2008. p. 2066-2067 4803674.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Saliev, T, Mullan, MJ, Cui, Y & Campbell, PA 2008, Characterization of sonicated breath films by Atomic Force Microscopy. in Proceedings - IEEE Ultrasonics Symposium., 4803674, pp. 2066-2067, 2008 IEEE International Ultrasonics Symposium, IUS 2008, Beijing, China, 11/2/08. https://doi.org/10.1109/ULTSYM.2008.0510
Saliev T, Mullan MJ, Cui Y, Campbell PA. Characterization of sonicated breath films by Atomic Force Microscopy. In Proceedings - IEEE Ultrasonics Symposium. 2008. p. 2066-2067. 4803674 https://doi.org/10.1109/ULTSYM.2008.0510
Saliev, T. ; Mullan, M. J. ; Cui, Y. ; Campbell, P. A. / Characterization of sonicated breath films by Atomic Force Microscopy. Proceedings - IEEE Ultrasonics Symposium. 2008. pp. 2066-2067
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