Characterization of the antibiotic compound no. 70 produced by Streptomyces sp. IMV-70

Lyudmila P. Trenozhnikova, Almagul K. Khasenova, Assya S. Balgimbaeva, Galina B. Fedorova, Genrikh S. Katrukha, Nina L. Tokareva, Boo H. Kwa, Azliyati Azizan

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Abstract

We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified as Streptomyces sp. IMV-70. In the process of fermentation, the strain Streptomyces spp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics.

Original languageEnglish
Article number594231
JournalThe Scientific World Journal
Volume2012
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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    Trenozhnikova, L. P., Khasenova, A. K., Balgimbaeva, A. S., Fedorova, G. B., Katrukha, G. S., Tokareva, N. L., Kwa, B. H., & Azizan, A. (2012). Characterization of the antibiotic compound no. 70 produced by Streptomyces sp. IMV-70. The Scientific World Journal, 2012, [594231]. https://doi.org/10.1100/2012/594231